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FLASH GENE
Symbol PLD3 contributors: - updated : 22-12-2006
HGNC name phospholipase D3
HGNC id 17158
Location 19q13.2      Physical location : 40.854.331 - 40.884.389
Synonym name
  • HindIII K4L
  • phospholipase D3
  • Synonym symbol(s) HU-K4
    DNA
    TYPE functioning gene
    STRUCTURE 29.00 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text extensive alternative splicing in the 5' untranslated region
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 1954 - 490 - Russo
    - - 2131 - 437 - Russo
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestivestomach   highly
    Nervousbrain   predominantly
    Reproductivefemale systembreast   
     female systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Pld3
    Homologene
    FAMILY phospholipase D superfamily
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    text having a type 2 transmembrane topology
    basic FUNCTION
  • phospholipase activity
  • may have a house-keeping function
  • in response to ARF, alters the lipid content of membranes, converting phospholipids into phosphatidic acid
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by ADP ribosylation factor (ARF)
    Other brefeldin blocks PLD3 activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS