SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytosolic
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| intracellular,cytoplasm,cytoskeleton,microtubule
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| text
| anchored at the outer mitochondrial membrane and mediates fusion of the outer membrane  |
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located on both mitochondria and ER |
| basic FUNCTION
| may play a role in the pathophysiology of obesity |
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regulating the mitochondrial network architecture by fusion of mitochondria required to maintain the functional peripheral nerve axon |
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involved in mitochondrial biogenesis, mediating intermitochondrial adhesion and retraction from the cell periphery and accumulation in the perinuclear region, and playing a role in mitochondrial fusion, required for proper mitochondrial distribution and outgrowth of dendritic spines in Purkinje cells |
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required for postnatal development of the cerebellum (Purkinje cells require MFN2 for dendritic outgrowth, spine formation, and cell survival) |
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having a signaling role in the regulation of apoptosis that extends beyond its role in mitochondrial fusion |
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regulating the mitochondrial fusion with MFN1 and OPA1 |
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key components in mitochondrial membrane fusion and division |
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dynamin-like GTPase required for mitochondrial fusion |
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tethers ER to mitochondria, a juxtaposition required for efficient mitochondrial Ca(2+) uptake |
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acts as an inhibitor of antiviral signaling, a function that may be distinct from its role in mitochondrial dynamics |
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tethering the endoplasmic reticulum and mitochondria to control the efficiency of mitochondrial uptake of Ca2+ ions |
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has lower GTPase activity and is thought to stabilize the interactions between mitochondria |
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regulates shape of the ER and tethers it to mitochondria, by engaging in homo- and hetero-complexes comprising MFN2 at the ER and MFN2 or MFN1 on mitochondria |
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role for mitofusins in directly regulating mitochondrial transport and offer important insight into the cell type specificity and molecular mechanisms of axonal degeneration in CMT2A and dominant optic atrophy |
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suppressor of cell proliferation that may also exert apoptotic effects via the mitochondrial apoptotic pathway |
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ubiquitination of MFN1 and MFN2 play a role in PINK1/PARK2-mediated mitophagy |
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dynamin-like protein that is involved in the rearrangement of the outer mitochondrial membrane |
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mediator of mitochondrial fusion, an evolutionarily conserved process responsible for the surveillance of mitochondrial homeostasis |
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in cardiac myocytes, controls mitochondrial morphogenesis and serves to predispose cells to mitochondrial permeability transition and to trigger cell death |
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important component in the mechanism whereby mitochondrial depolarization inhibits CRAC (Ca2+ release-activated Ca2+ channel) activity |
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mitochondrial MFN2 is involved in regulating store-operated calcium entry after mitochondrial depolarization |
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might serve as a brake, inhibiting Ca2+ entry only after mitochondria depolarize |
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MFN1 and MFN2 function to maintain mitochondrial networks by binding one another and initiating outer mitochondrial membrane fusion |
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mitochondrial dynamics, particularly those mediated by the mitofusins, play a role in endothelial cell function and viability |
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unique unexpected role of MFN2 coordinating mitochondria and endoplasmic reticulum function, leading to modulation of insulin signaling and glucose homeostasis |
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is an ER stress-inducible factor that contributes to ER homeostasis |
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MFN2 but not MFN1 is an ER stress-inducible protein that is required for the proper temporal sequence of the ER stress response |
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is an ER stress-inducible protein that is required for the adaptation of the ER to stress |
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serves as a major determinant of cardiomyocyte apoptosis mediated by oxidative stress |
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novel and essential role of MFN2 in mediating cardiac autophagy |
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MFN2, but not MFN1, is required for axonal projections of dopamine (DA) neurons |
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does not play a critical role in the juxtapostion of ER and mitochondria |
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MFN1, MFN2, PARK2 regulating mitochondrial spheroid formation and mitophagy that could represent different strategies of mitochondrial homeostatic response to oxidative stress |
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participates in mitochondrial fusion, is required to maintain normal mitochondrial metabolism in skeletal muscle and liver |
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crucial involvement in mediating ER stress-induced leptin resistance |
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mitochondria and melanosomes establish physical contacts modulated by MFN2 and involved in organelle biogenesis |
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mitochondrial fusion protein that is critical for mitochondrial DNA integrity and function |
