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FLASH GENE
Symbol TRPC4AP contributors: mct - updated : 04-03-2011
HGNC name transient receptor potential cation channel, subfamily C, member 4 associated protein
HGNC id 16181
PROTEIN
PHYSICAL PROPERTIES globular Hydrophobic
STRUCTURE
motifs/domains
  • the entire N-terminal region (AAs 1-440) is involved in its interaction with TNFRSF1A and within this region, AAs 249-440 play an important role, and also also important for the interaction with TRAF2
  • putative ser/thr and tyr kinase phosphorylation sites
  • two putative TRAF2 binding sites
  • C-terminal region may contribute to its oligomerization
    • mono polymer monomer , trimer
    HOMOLOGY
    interspecies homolog to rattus Trpc4ap (97.74 pc)
    homolog to murine Trpc4ap (97.47 pc)
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    basic FUNCTION
  • transporter activity
  • may be participating in the activation of NFKB1 in response to TNFRSF1A ligation
  • could serve as a scaffolding protein to link to TNFRSF1A to the IKK signaling complex
  • suppresses Myc-mediated transactivation and transformation in a dose-dependent manner
  • may contribute to the regulation of TNFRSF1A signaling, possibly by facilitating the assembly and/or dissociation of TNFRSF1A signaling complexes
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling signal transduction
    a component may exist both as a monomeric species (90 kDa) and as homomeric complexes, including a trimer (270 kDa)
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP binding
    protein
  • constitutively associated with TNFRSF1A
  • interacts with TRADD, TRAF2, CHUK, IKBKB, IKBKG
  • TAP1, TAP2 binding
  • activating AP1 & JNK
  • receptor for a DDB1 (damage-specific DNA-binding protein 1)-CUL4 (Cullin 4) E3 ligase complex for selective Myc degradation through the proteasome
  • binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus
  • interacted with only TNFRSF1A, TRAF2, and IKBKG
  • interacts with TNFRSF1A through an N-Terminal region containing AAs 249-440
  • binds to TRAF2 in a manner independent of these putative TRAF2 binding motifs
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in most cancer cell lines, leading to Myc protein stabilization
    Susceptibility to Alzheimer disease
    Variant & Polymorphism other haplotype identified in two extended pedigrees with late-onset Alzheimer disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS