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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

LRRC4

contributors: mct - updated : 31-10-2013

HGNC name	leucine rich repeat containing 4
HGNC id	15586

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOI     epigenetically inactivated commonly in glioma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain glioma/neuroblstoma modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma

ANIMAL & CELL MODELS

	in netrin-G1- and -G2-deficient mice, in which axonal path-finding is normal, the segmental distribution of NGL-1 and -2 is selectively disrupted, and the individual receptors are diffused along the dendrites
	in Ngl-2-/- mice, we find specific defects in the assembly of presynaptic ribbons in rods, indicating that reverse signaling of complexes involving NGL-2 regulates presynaptic maturation