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FLASH GENE
Symbol LRRC4 contributors: mct - updated : 31-10-2013
HGNC name leucine rich repeat containing 4
HGNC id 15586
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 3723 - 653 - 2004 15967442
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouth   highly
Nervousbrainlimbic systemhippocampusdentate gyruspredominantly Homo sapiens
 braindiencephalonthalamusnucleihighly Homo sapiens
 brainhindbraincerebellum highly Homo sapiensAdult
cells
SystemCellPubmedSpeciesStageRna symbol
NervousPurkinje cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine leucine rich repeats and an immunoglobulin domain
HOMOLOGY
Homologene
FAMILY LRR superfamily
CATEGORY regulatory , tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane,junction
text
  • surface bound or soluble protein
  • concentrated in distinct dendritic segments corresponding to the termination of netrin-G2-positive axons
  • LRRC4, LRRC4B, LRRC4C are mainly localized to the postsynaptic side of excitatory synapses
  • basic FUNCTION
  • stimulates/disrupts the growth of embryonic thalamic axon, depending of its form, surface bound/soluble protein
  • may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system
  • participates in the differentiation of neuron and glia cells
  • regulate axonal outgrowth and lamina-specific dendritic segmentation, suggesting that the NGL-dependent adhesion system is important for the development of axons, dendrites, and synapses
  • at least partially by down-regulating the STMN1expression, acts as a major glioma suppressor, induces cell cycle arrest and modulates the dynamic process of microtubulin, leading to the inhibition of glioma cell proliferation and growth
  • key regulator of input-specific synapse development in the hippocampus
  • is critical for pathway-specific synapse development and functional integration of distinct inputs
  • is a central component of pathway-specific development in the outer retina
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with NG1 via immunoglobulin domains
  • interact with the presynaptic ligands netrin-G2
  • interact with the abundant postsynaptic density (PSD) protein, DLG4, and other postsynaptic proteins, including NMDA receptors
  • LRRC4 binds to the PDZ domain of PARD6A, and interacts with PARD3
  • cell & other
    REGULATION
    Other down-regulated in primary brain tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOI    
    epigenetically inactivated commonly in glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma
    ANIMAL & CELL MODELS
  • in netrin-G1- and -G2-deficient mice, in which axonal path-finding is normal, the segmental distribution of NGL-1 and -2 is selectively disrupted, and the individual receptors are diffused along the dendrites
  • in Ngl-2-/- mice, we find specific defects in the assembly of presynaptic ribbons in rods, indicating that reverse signaling of complexes involving NGL-2 regulates presynaptic maturation