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FLASH GENE
Symbol LRRC4 contributors: mct - updated : 31-10-2013
HGNC name leucine rich repeat containing 4
HGNC id 15586
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
nine leucine rich repeats and an immunoglobulin domain
HOMOLOGY
Homologene
FAMILY LRR superfamily
CATEGORY regulatory , tumor suppressor
SUBCELLULAR LOCALIZATION     plasma membrane,junction
text
  • surface bound or soluble protein
  • concentrated in distinct dendritic segments corresponding to the termination of netrin-G2-positive axons
  • LRRC4, LRRC4B, LRRC4C are mainly localized to the postsynaptic side of excitatory synapses
  • basic FUNCTION
  • stimulates/disrupts the growth of embryonic thalamic axon, depending of its form, surface bound/soluble protein
  • may play an important role in maintaining normal function and suppressing tumorigenesis in the central nervous system
  • participates in the differentiation of neuron and glia cells
  • regulate axonal outgrowth and lamina-specific dendritic segmentation, suggesting that the NGL-dependent adhesion system is important for the development of axons, dendrites, and synapses
  • at least partially by down-regulating the STMN1expression, acts as a major glioma suppressor, induces cell cycle arrest and modulates the dynamic process of microtubulin, leading to the inhibition of glioma cell proliferation and growth
  • key regulator of input-specific synapse development in the hippocampus
  • is critical for pathway-specific synapse development and functional integration of distinct inputs
  • is a central component of pathway-specific development in the outer retina
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with NG1 via immunoglobulin domains
  • interact with the presynaptic ligands netrin-G2
  • interact with the abundant postsynaptic density (PSD) protein, DLG4, and other postsynaptic proteins, including NMDA receptors
  • LRRC4 binds to the PDZ domain of PARD6A, and interacts with PARD3
  • cell & other
    REGULATION
    Other down-regulated in primary brain tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOI    
    epigenetically inactivated commonly in glioma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    modulation of LRRC4 or STMN1 expression may be useful for design of new therapies for the intervention of glioma
    ANIMAL & CELL MODELS
  • in netrin-G1- and -G2-deficient mice, in which axonal path-finding is normal, the segmental distribution of NGL-1 and -2 is selectively disrupted, and the individual receptors are diffused along the dendrites
  • in Ngl-2-/- mice, we find specific defects in the assembly of presynaptic ribbons in rods, indicating that reverse signaling of complexes involving NGL-2 regulates presynaptic maturation