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FLASH GENE
Symbol CNOT7 contributors: SGE/mct - updated : 12-06-2019
HGNC name CCR4-NOT transcription complex, subunit 7
HGNC id 14101
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • CAF1 family ribonuclease motif
    • mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Caf1
    intraspecies paralog to POP2
    Homologene
    FAMILY
  • CAF1 family
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    text
  • PRMT1 colocalize in nuclear speckles, a sub-nuclear compartment enriched in small nuclear ribonucleoproteins and splicing factors
    • basic FUNCTION
  • regulates PRMT1 activity in a substrate-dependent manner (have been involved in the regulation of transcription and RNA metabolism, and likely could contribute to the crosstalk between transcription and RNA processing)
  • deadenylase CNOT7 dynamically regulates dendritic mRNA translation and transport, as well as synaptic plasticity and higher cognitive function
  • important regulator of RNA transport and translation in dendrites, as well as higher cognitive function
  • is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm
  • CNOT7/8 catalytic subunits are essential for deadenylation, which is necessary to maintain cell viability, whereas CNOT6/6L are not
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling signal transduction
    a component
  • component of CCR4 complex
  • complex of BTG4 and CNOT7, CNOT8 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BTG1
  • interacting with PRMT1
  • interacting with BTG2 (Yang, 2008)
  • anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes
  • CNOT7, CNOT8 cooperate with CNOT6, CNOT6L in mRNA deadenylation, suggesting that the enzyme activities of CNOT7, CNOT8 and CNOT6, CNOT6L are regulated via allosteric interactions within the nuclease module
  • BTG2 bridges PABPC1 RNA-binding domains and CNOT7, CNOT8 deadenylase to control cell proliferation
  • BTG4 bridged CNOT7, a catalytic subunit of the CCR4-NOT deadenylase, to eIF4E, a key translation initiation factor
  • CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTP&
    • 8209;mediated ICAM1 and IL8 mRNA decay
  • EIF4A2 does not inhibit CNOT7 association with the CCR4-NOT complex but instead inhibits CNOT7 activity
  • BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in mice, Cnot7 is essential for hippocampal-dependent learning and memory