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FLASH GENE
Symbol CNOT7 contributors: SGE/mct - updated : 12-06-2019
HGNC name CCR4-NOT transcription complex, subunit 7
HGNC id 14101
Location 8p22      Physical location : 17.086.739 - 17.104.387
Synonym name
  • BTG1 binding factor 1
  • carbon catabolite repressor protein (CCR4)-associative factor 1
  • Synonym symbol(s) CAF1, hCAF-1, Caf1a, CAF-1
    EC.number 3.1.13.4
    DNA
    TYPE functioning gene
    STRUCTURE 24.88 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text two alternative spliced transcripts
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 6890 - 285 - 2019 31180491
    full length isoform, CNOT7V1
    6 splicing 1922 - 244 displays a distinct expression profile in human tissues, as well as a nuclear sub-cellular localization compared to CNOT7v1 2017 28591869
  • CNOT7V2
  • uses alternate splice sites in the last exon, resulting in a frameshift and an earlier codon stop. Shorter than isoform 1 and a distinct C terminus
  • regulates the inclusion of CD44 variable exons
  • preferential involvement of CNOT7v2 in nuclear processes, such as arginine methylation and alternative splicing, rather than mRNA turnover
  • 8 - 6956 - 307 - 2019 31180491
    8 - 6994 - 204 - 2019 31180491
    8 - 7071 - 204 - 2019 31180491
    8 - 6965 - 285 - 2019 31180491
    7 - 6780 - 285 - 2019 31180491
    8 - 6961 - 204 - 2019 31180491
    8 - 6865 - 285 - 2019 31180491
    8 - 1956 - 256 - 2019 31180491
    8 - 1991 - 163 - 2019 31180491
    7 - 2103 - 163 - 2019 31180491
    7 - 2026 - 163 - 2019 31180491
    6 - 2057 - 244 - 2019 31180491
    6 - 1812 - 244 - 2019 31180491
    7 - 1997 - 244 - 2019 31180491
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
    Reproductivemale systemtestis  highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa)  
    Muscularstriatumskeletal highly
    cell lineage colonic mucosa and colonic crypt cells
    cell lines colorectal cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • CAF1 family ribonuclease motif
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to murine Caf1
    intraspecies paralog to POP2
    Homologene
    FAMILY
  • CAF1 family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    intracellular,nucleus,nucleoplasm,nuclear bodies,PML
    text
  • PRMT1 colocalize in nuclear speckles, a sub-nuclear compartment enriched in small nuclear ribonucleoproteins and splicing factors
  • basic FUNCTION
  • regulates PRMT1 activity in a substrate-dependent manner (have been involved in the regulation of transcription and RNA metabolism, and likely could contribute to the crosstalk between transcription and RNA processing)
  • deadenylase CNOT7 dynamically regulates dendritic mRNA translation and transport, as well as synaptic plasticity and higher cognitive function
  • important regulator of RNA transport and translation in dendrites, as well as higher cognitive function
  • is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm
  • CNOT7/8 catalytic subunits are essential for deadenylation, which is necessary to maintain cell viability, whereas CNOT6/6L are not
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling signal transduction
    a component
  • component of CCR4 complex
  • complex of BTG4 and CNOT7, CNOT8 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BTG1
  • interacting with PRMT1
  • interacting with BTG2 (Yang, 2008)
  • anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes
  • CNOT7, CNOT8 cooperate with CNOT6, CNOT6L in mRNA deadenylation, suggesting that the enzyme activities of CNOT7, CNOT8 and CNOT6, CNOT6L are regulated via allosteric interactions within the nuclease module
  • BTG2 bridges PABPC1 RNA-binding domains and CNOT7, CNOT8 deadenylase to control cell proliferation
  • BTG4 bridged CNOT7, a catalytic subunit of the CCR4-NOT deadenylase, to eIF4E, a key translation initiation factor
  • CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTP&
  • 8209;mediated ICAM1 and IL8 mRNA decay
  • EIF4A2 does not inhibit CNOT7 association with the CCR4-NOT complex but instead inhibits CNOT7 activity
  • BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • in mice, Cnot7 is essential for hippocampal-dependent learning and memory