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FLASH GENE

Symbol

CNOT7

contributors: SGE/mct - updated : 12-06-2019

HGNC name	CCR4-NOT transcription complex, subunit 7
HGNC id	14101

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine         Reproductive male system testis     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial absorptive excretory digestive epithelium (mucosa)     Muscular striatum skeletal   highly

cell lineage	colonic mucosa and colonic crypt cells
cell lines	colorectal cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

CAF1 family ribonuclease motif

mono polymer

complex

HOMOLOGY

interspecies

homolog to murine Caf1

intraspecies

paralog to POP2

Homologene

FAMILY

CAF1 family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
	intracellular,nucleus,nucleoplasm,nuclear bodies,PML
text	PRMT1 colocalize in nuclear speckles, a sub-nuclear compartment enriched in small nuclear ribonucleoproteins and splicing factors

basic FUNCTION	regulates PRMT1 activity in a substrate-dependent manner (have been involved in the regulation of transcription and RNA metabolism, and likely could contribute to the crosstalk between transcription and RNA processing)
	deadenylase CNOT7 dynamically regulates dendritic mRNA translation and transport, as well as synaptic plasticity and higher cognitive function
	important regulator of RNA transport and translation in dendrites, as well as higher cognitive function
	is a catalytic subunit of the CCR4-NOT complex, which has been implicated in all aspects of the mRNA life cycle, from mRNA synthesis in the nucleus to degradation in the cytoplasm
	CNOT7/8 catalytic subunits are essential for deadenylation, which is necessary to maintain cell viability, whereas CNOT6/6L are not

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

carbohydrate

signaling

signal transduction

a component	component of CCR4 complex
	complex of BTG4 and CNOT7, CNOT8 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs

INTERACTION

DNA

RNA

small molecule

protein	BTG1
	interacting with PRMT1
	interacting with BTG2 (Yang, 2008)
	anti-proliferative activity of BTG1, BTG2, BTG3, BTG4, TOB1, TOB2 proteins is mediated through interactions with the CNOT7, CNOT8 deadenylase enzymes
	CNOT7, CNOT8 cooperate with CNOT6, CNOT6L in mRNA deadenylation, suggesting that the enzyme activities of CNOT7, CNOT8 and CNOT6, CNOT6L are regulated via allosteric interactions within the nuclease module
	BTG2 bridges PABPC1 RNA-binding domains and CNOT7, CNOT8 deadenylase to control cell proliferation
	BTG4 bridged CNOT7, a catalytic subunit of the CCR4-NOT deadenylase, to eIF4E, a key translation initiation factor
	CNOT1 provides a platform for the recruitment of TTP and CNOT7, and is involved in TTP&
	8209;mediated ICAM1 and IL8 mRNA decay
	EIF4A2 does not inhibit CNOT7 association with the CCR4-NOT complex but instead inhibits CNOT7 activity
	BTG4 functions as an adaptor by recruiting the CCR4-NOT catalytic subunits CNOT7 and CNOT8, which are involved in mRNA decay

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

in mice, Cnot7 is essential for hippocampal-dependent learning and memory