Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SERPINE2

contributors: mct/npt - updated : 10-04-2010

HGNC name	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
HGNC id	8951

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pancreatic carcinoma constitutional     --low   significantly decreased in HELLP placentas tumoral     --over   in pancreatic and mammary cancer cell-lines with a high metastatic potential, compared with those in a rarely metastatic cell-line (Nagahara 2010)

Susceptibility

to chronic obstructive pulmonary disease

Variant & Polymorphism SNP	a SNP increasing the risk of chronic obstructive pulmonary disease, likely influenced by gene-by-smoking interaction
	Six SNPs demonstrated significant associations with COPD phenotypes in the family-based association analysis (Zhu 2007)

Candidate gene	potential biomarker that might be tested clinically
	in patients for early diagnosis of HELLP syndrome Kang 2008)
Marker
Therapy target	secreted protein, that could be a new target for the therapy against human testicular germ cell tumor (Nagahara 2010)

ANIMAL & CELL MODELS