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FLASH GENE
Symbol SERPINE2 contributors: mct/npt - updated : 10-04-2010
HGNC name serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
HGNC id 8951
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 28 amino acids at the N-terminus identical to the N-terminal amino acid sequence of a glial-derived neurite promoting factor
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • serpin family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction
    text neuromuscular junctions
    basic FUNCTION
  • serine proteinase inhibitor, promoting neurite outgrowth
  • regulator of alpha-thrombin
  • may play a much larger role in the modeling and remodeling of brain tissues during development
  • potent urinary plasminogen activator inhibitor in the presence of collagen type IV and may play a much larger role in the modeling and remodeling of brain tissues during development (Crisp 2002)
  • possible promoter of testicular germ cell tumors lymph node metastasis (Nagahara 2010)
  • inhibits FURIN, a serine protease that activates MMP17 involved in the shedding of endothelial PROCR, suggesting a direct interaction between SERPINE2 and FURIN in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in pancreatic carcinoma
    constitutional     --low  
    significantly decreased in HELLP placentas
    tumoral     --over  
    in pancreatic and mammary cancer cell-lines with a high metastatic potential, compared with those in a rarely metastatic cell-line (Nagahara 2010)
    Susceptibility to chronic obstructive pulmonary disease
    Variant & Polymorphism SNP
  • a SNP increasing the risk of chronic obstructive pulmonary disease, likely influenced by gene-by-smoking interaction
  • Six SNPs demonstrated significant associations with COPD phenotypes in the family-based association analysis (Zhu 2007)
  • Candidate gene potential biomarker that might be tested clinically
    in patients for early diagnosis of HELLP syndrome Kang 2008)
    Marker
    Therapy target
  • secreted protein, that could be a new target for the therapy against human testicular germ cell tumor (Nagahara 2010)
  • ANIMAL & CELL MODELS