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FLASH GENE

Symbol

SERPINE2

contributors: mct/npt - updated : 10-04-2010

HGNC name	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
HGNC id	8951

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Nervous brain       highly Reproductive female system placenta     highly Skin/Tegument skin       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

28 amino acids at the N-terminus identical to the N-terminal amino acid sequence of a glial-derived neurite promoting factor

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

serpin family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane,junction
text	neuromuscular junctions

basic FUNCTION	serine proteinase inhibitor, promoting neurite outgrowth
	regulator of alpha-thrombin
	may play a much larger role in the modeling and remodeling of brain tissues during development
	potent urinary plasminogen activator inhibitor in the presence of collagen type IV and may play a much larger role in the modeling and remodeling of brain tissues during development (Crisp 2002)
	possible promoter of testicular germ cell tumors lymph node metastasis (Nagahara 2010)
	inhibits FURIN, a serine protease that activates MMP17 involved in the shedding of endothelial PROCR, suggesting a direct interaction between SERPINE2 and FURIN in endothelial cells

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

reproduction/sex

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in pancreatic carcinoma constitutional     --low   significantly decreased in HELLP placentas tumoral     --over   in pancreatic and mammary cancer cell-lines with a high metastatic potential, compared with those in a rarely metastatic cell-line (Nagahara 2010)

Susceptibility

to chronic obstructive pulmonary disease

Variant & Polymorphism SNP	a SNP increasing the risk of chronic obstructive pulmonary disease, likely influenced by gene-by-smoking interaction
	Six SNPs demonstrated significant associations with COPD phenotypes in the family-based association analysis (Zhu 2007)

Candidate gene	potential biomarker that might be tested clinically
	in patients for early diagnosis of HELLP syndrome Kang 2008)
Marker
Therapy target	secreted protein, that could be a new target for the therapy against human testicular germ cell tumor (Nagahara 2010)

ANIMAL & CELL MODELS