|
| Nrf2(-/-) mice were highly susceptible to N-acetyl-p-aminophenol treatment and died of liver failure  |
|
mice targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia due to increased sequestration of damaged erythrocytes . |
|
Nrf2-deficient mice show decolourization of the incisors |
|
Disruption of the Nrf2 gene in mice led to earlier-onset and more extensive cigarette smoke-induced emphysema |
|
Disruption of Nrf2 dramatically increased the mortality of mice in response to endotoxin- and cecal ligation and puncture-induced septic shock |
|
Nrf2-deficient mice developed tumors more readily in response to carcinogen exposure and caloric exposure was ineffective in suppressing tumors in the KO mice |
|
expression levels of NRF1 is significantly decreased in both Alzheimer's disease hippocampal tissues and AD-causing amyloid precursor protein mutant cells |
|
Nrf2-null mice develop diffuse white matter injury without overt loss of neurons |
|
Nrf2 KO mice during acidosis showed increased expression of renal markers of oxidative stress and injury and Nrf2 activity was increased during metabolic acidosis in WT kidney |