Citations for
1GPX7, NFE2L2
Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7.
Fang J, Yang J, Wu X, Zhang G, Li T, Wang X, Zhang H, Wang CC, Liu GH, Wang L.
Aging Cell 17(4):e12765. doi: 10.1111/acel.12765. Epub 2018 Apr 16. 2018
2KEAP1, NFE2L2, PGAM5
A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM.
J Cell Sci 130(20):3467-3480. doi: 10.1242/jcs.203216. Epub 2017 Aug 24. 2017
3NFE2L2, SIRT2
Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2.
Yang X, Park SH, Chang HC, Shapiro JS, Vassilopoulos A, Sawicki KT, Chen C, Shang M, Burridge PW, Epting CL, Wilsbacher LD, Jenkitkasemwong S, Knutson M, Gius D, Ardehali H.
J Clin Invest 127(4):1505-1516. doi: 10.1172/JCI88574. Epub 2017 Mar 13. 2017
4CORD25, NFE2L2, RCBTB1, RDEOA
Isolated and Syndromic Retinal Dystrophy Caused by Biallelic Mutations in RCBTB1, a Gene Implicated in Ubiquitination.
Coppieters F, Ascari G, Dannhausen K, Nikopoulos K, Peelman F, Karlstetter M, Xu M, Brachet C, Meunier I, Tsilimbaris MK, Tsika C, Blazaki SV, Vergult S, Farinelli P, Van Laethem T, Bauwens M, De Bruyne M, Chen R, Langmann T, Sui R, Meire F, Rivolta C, Hamel CP, Leroy BP, De Baere E.
Am J Hum Genet 99(2):470-80. doi: 10.1016/j.ajhg.2016.06.017. 2016
5NFE2L2
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.
Pajares M, Jiménez-Moreno N, García-Yagüe ÁJ, Escoll M, de Ceballos ML, Van Leuven F, Rábano A, Yamamoto M, Rojo AI, Cuadrado A.
Autophagy utophagy. 2016 Jul 18:1-15. [Epub ahead of print] 2016
6BACH1, BACH2, MAFG, MAFK, MAfF, NFE2, NFE2L2
Small Maf proteins (MafF, MafG, MafK): History, structure and function.
Katsuoka F, Yamamoto M.
Gene 586(2):197-205. doi: 10.1016/j.gene.2016.03.058. Epub 2016 Apr 5. Review. 2016
7GBE1, NFE2L2, PHKA1
Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism.
Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal SS, Yamamoto M.
Mol Cell Biol 36(11):1655-72. doi: 10.1128/MCB.01095-15. 2016
8IL36G, NFE2L2
Autocrine and Paracrine Regulation of Keratinocyte Proliferation through a Novel Nrf2-IL-36γ Pathway.
Kurinna S, Muzumdar S, Köhler UA, Kockmann T, Auf dem Keller U, Schäfer M, Werner S.
J Immunol 196(11):4663-70. doi: 10.4049/jimmunol.1501447. Epub 2016 Apr 25. 2016
9NFE2L2, PBK
PBK/TOPK mediates promyelocyte proliferation via Nrf2-regulated cell cycle progression and apoptosis.
Liu Y, Liu H, Cao H, Song B, Zhang W, Zhang W.
Oncol Rep 34(6):3288-96. 2015
10HAMP, NFE2L2
Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption.
Bayele HK, Balesaria S, Srai SK.
Free Radic Biol Med 89:1192-202. doi: 10.1016/j.freeradbiomed.2015.11.001. Epub 2015 Nov 10. 2015
11CACUL1, NFE2L2
CACUL1/CAC1 Regulates the Antioxidant Response by Stabilizing Nrf2.
Kigoshi Y, Fukuda T, Endo T, Hayasaka N, Iemura S, Natsume T, Tsuruta F, Chiba T.
Sci Rep 5:12857. doi: 10.1038/srep12857. 2015
12HOTAIR, NFE2L2
Low long non-coding RNA HOTAIR expression is associated with down-regulation of Nrf2 in the spermatozoa of patients with asthenozoospermia or oligoasthenozoospermia.
Zhang L, Liu Z, Li X, Zhang P, Wang J, Zhu D, Chen X, Ye L.
Int J Clin Exp Pathol 8(11):14198-205. eCollection 2015. 2015
13AXIN1, NFE2L2, WNT3A
WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.
Rada P, Rojo AI, Offergeld A, Feng GJ, Velasco-Martin JP, Gonzalez Sancho JM, Valverde A, Dale T, Regadera J, Cuadrado A.
Antioxid Redox Signal ntioxid Redox Signal. 2014 Oct 21. [Epub ahead of print] 2014
14KEAP1, NFE2L2
Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.
Murakami S, Shimizu R, Romeo PH, Yamamoto M, Motohashi H.
Genes Cells 19(3):239-53. doi: 10.1111/gtc.12126. Epub 2014 Jan 21. 2014
15HMOX1, NFE2L2
Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses.
Biswas C, Shah N, Muthu M, La P, Fernando AP, Sengupta S, Yang G, Dennery PA.
J Biol Chem 289(39):26882-94. doi: 10.1074/jbc.M114.567685. Epub 2014 Aug 8. 2014
16HMOX1, NFE2L2
Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1.
Na HK, Surh YJ.
Free Radic Biol Med 67:353-65. doi: 10.1016/j.freeradbiomed.2013.10.819. Epub 2013 Nov 5. Review. 2014
17HACE1, NFE2L2
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH.
Proc Natl Acad Sci U S A 111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. 2014
18NFE2L2
Neuronal activity regulates astrocytic Nrf2 signaling.
Habas A, Hahn J, Wang X, Margeta M.
Proc Natl Acad Sci U S A 110(45):18291-6. doi: 10.1073/pnas.1208764110. Epub 2013 Oct 21. 2013
19NFE2L2, RXRA
RXRα inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2.
Wang H, Liu K, Geng M, Gao P, Wu X, Hai Y, Li Y, Li Y, Luo L, Hayes JD, Wang XJ, Tang X.
Cancer Res 73(10):3097-108. doi: 10.1158/0008-5472.CAN-12-3386. Epub 2013 Apr 23. 2013
20KEAP1, NFE2L2, SQSTM1
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M.
Mol Cell 51(5):618-31. doi: 10.1016/j.molcel.2013.08.003. Epub 2013 Sep 5. 2013
21KEAP1, NFE2L2
The Keap1/Nrf2 protein axis plays a role in osteoclast differentiation by regulating intracellular reactive oxygen species signaling.
Kanzaki H, Shinohara F, Kajiya M, Kodama T.
J Biol Chem 288(32):23009-20. doi: 10.1074/jbc.M113.478545. Epub 2013 Jun 25. Erratum in: J Biol Chem. 2014 Feb 28;289(9):5536. 2013
22KEAP1, NFE2L2, USP15
USP15 negatively regulates Nrf2 through deubiquitination of Keap1.
Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD.
Mol Cell 51(1):68-79. doi: 10.1016/j.molcel.2013.04.022. Epub 2013 May 30. 2013
23KEAP1, NFE2L2
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
Cancer Res 73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4. 2013
24KEAP1, NFE2L2
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
Cancer Res 73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4. 2013
25AMER1, KEAP1, NFE2L2, SQSTM1
Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination.
Hast BE, Goldfarb D, Mulvaney KM, Hast MA, Siesser PF, Yan F, Hayes DN, Major MB.
Cancer Res 73(7):2199-210. doi: 10.1158/0008-5472.CAN-12-4400. Epub 2013 Feb 4. 2013
26NFE2L2, THOC1
The suppression of thoc1 in cancer cell apoptosis mediated by activated macrophages is nitric oxide-dependent.
Lin YS, Lin CH, Huang LD, Chao T, Kuo CD, Hung LC, Wong FH, Lin CC, Fu SL.
Biochem Pharmacol 86(2):242-52. doi: 10.1016/j.bcp.2013.05.009. Epub 2013 May 17. 2013
27JDP2, MAFK, NFE2L2
Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.
Tanigawa S, Lee CH, Lin CS, Ku CC, Hasegawa H, Qin S, Kawahara A, Korenori Y, Miyamori K, Noguchi M, Lee LH, Lin YC, Steve Lin CL, Nakamura Y, Jin C, Yamaguchi N, Eckner R, Hou DX, Yokoyama KK.
Cell Death Dis 4:e921. doi: 10.1038/cddis.2013.448. Erratum in: Cell Death Dis. 2014;5:e1344. 2013
28JDP2, MAFK, NFE2L2
Control of Oxidative Stress and Generation of Induced Pluripotent Stem Cell-like Cells by Jun Dimerization Protein 2.
Chiou SS, Wang SS, Wu DC, Lin YC, Kao LP, Kuo KK, Wu CC, Chai CY, Lin CL, Lee CY, Liao YM, Wuputra K, Yang YH, Wang SW, Ku CC, Nakamura Y, Saito S, Hasegawa H, Yamaguchi N, Miyoshi H, Lin CS, Eckner R, Yokoyama KK.
Cancers (Basel) 5(3):959-84. doi: 10.3390/cancers5030959. 2013
29NFE2L2, NRF1, PPARGC1A, TFAM
Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease.
Sheng B, Wang X, Su B, Lee HG, Casadesus G, Perry G, Zhu X.
J Neurochem. 120(3):419-29 2012
30NFE2L2
Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation.
Kim SB, Pandita RK, Eskiocak U, Ly P, Kaisani A, Kumar R, Cornelius C, Wright WE, Pandita TK, Shay JW.
Proc Natl Acad Sci U S A 109(43):E2949-55. doi: 10.1073/pnas.1207718109. Epub 2012 Oct 8. 2012
31KEAP1, NFE2L2, PALB2
PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function.
Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung KL, Ganesan S, Kong AN, Zhang DD, Xia B.
Mol Cell Biol 32(8):1506-17. doi: 10.1128/MCB.06271-11. Epub 2012 Feb 13. 2012
32AMER1, KEAP1, NFE2L2
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein.
Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, Tang X, Zheng N, Major MB, Moon RT.
J Biol Chem 287(9):6539-50. doi: 10.1074/jbc.M111.316471. Epub 2012 Jan 3. 2012
33BCL2, KEAP1, NFE2L2
Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
Niture SK, Jaiswal AK.
J Biol Chem 287(13):9873-86. doi: 10.1074/jbc.M111.312694. Epub 2012 Jan 24. 2012
34NFE2L2, OLR1
Decreased lectin-like oxidized LDL receptor 1 (LOX-1) and low Nrf2 activation in placenta are involved in preeclampsia.
Chigusa Y, Tatsumi K, Kondoh E, Fujita K, Nishimura F, Mogami H, Konishi I.
J Clin Endocrinol Metab 97(10):E1862-70. doi: 10.1210/jc.2012-1268. Epub 2012 Jul 12. 2012
35CBR3, NFE2L2
A conserved antioxidant response element (ARE) in the promoter of human carbonyl reductase 3 (CBR3) mediates induction by the master redox switch Nrf2.
Cheng Q, Kalabus JL, Zhang J, Blanco JG.
Biochem Pharmacol 83(1):139-48. doi: 10.1016/j.bcp.2011.09.027. Epub 2011 Oct 5. 2012
36NFE2L2, NQO1, SQSTM1
Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade.
Kwon J, Han E, Bui CB, Shin W, Lee J, Lee S, Choi YB, Lee AH, Lee KH, Park C, Obin MS, Park SK, Seo YJ, Oh GT, Lee HW, Shin J.
EMBO Rep 13(2):150-6. doi: 10.1038/embor.2011.246. 2012
37KEAP1, NFE2L2
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses.
Palsamy P, Ayaki M, Elanchezhian R, Shinohara T.
Biochem Biophys Res Commun 423(3):542-8. doi: 10.1016/j.bbrc.2012.05.164. Epub 2012 Jun 7. 2012
38NFE2L2, PARK7, TXN
DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway.
Im JY, Lee KW, Woo JM, Junn E, Mouradian MM.
Hum Mol Genet 21(13):3013-24. doi: 10.1093/hmg/dds131. Epub 2012 Apr 5. 2012
39KEAP1, NFE2L2
Keap1 degradation by autophagy for the maintenance of redox homeostasis.
Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, Yamamoto M.
Proc Natl Acad Sci U S A 109(34):13561-6. doi: 10.1073/pnas.1121572109. Epub 2012 Aug 7. 2012
40BTG2, NFE2L2
B-cell translocation gene 2 (BTG2) stimulates cellular antioxidant defenses through the antioxidant transcription factor NFE2L2 in human mammary epithelial cells.
Karve TM, Rosen EM.
J Biol Chem 287(37):31503-14. doi: 10.1074/jbc.M112.367433. 2012
41MAPK7, NFE2L2
Laminar flow activation of ERK5 protein in vascular endothelium leads to atheroprotective effect via NF-E2-related factor 2 (Nrf2) activation.
Kim M, Kim S, Lim JH, Lee C, Choi HC, Woo CH.
J Biol Chem 287(48):40722-31. doi: 10.1074/jbc.M112.381509. Epub 2012 Oct 5. 2012
42MYD88, NFE2L2
MyD88 is a mediator for the activation of Nrf2.
Kim KH, Lyu JH, Koo ST, Oh SR, Lee HK, Ahn KS, Sadikot RT, Joo M.
Biochem Biophys Res Commun 404(1):46-51. Epub 2010 Nov 19. 2011
43HDAC2, NFE2L2
Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress.
Mercado N, Thimmulappa R, Thomas CM, Fenwick PS, Chana KK, Donnelly LE, Biswal S, Ito K, Barnes PJ.
Biochem Biophys Res Commun 406(2):292-8. Epub 2011 Feb 12. 2011
44AKR1B10, NFE2L2
Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity.
Díez-Dacal B, Gayarre J, Gharbi S, Timms JF, Coderch C, Gago F, Pérez-Sala D.
Cancer Res 71(12):4161-71. Epub 2011 Apr 20. 2011
45NFE2L2, TRIM28
The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response.
Maruyama A, Nishikawa K, Kawatani Y, Mimura J, Hosoya T, Harada N, Yamamato M, Itoh K.
Biochem J 436(2):387-97. 2011
46KRAS, MYC, NFE2L2
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.
Nature 475(7354):106-9. doi: 10.1038/nature10189. 2011
47NFE2L2
NRF2 targeting: a promising therapeutic strategy in chronic obstructive pulmonary disease.
Boutten A, Goven D, Artaud-Macari E, Boczkowski J, Bonay M.
Trends Mol Med 17(7):363-71. Epub 2011 Apr 1. Review. 2011
48KEAP1, NFE2L2
Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer.
Konstantinopoulos PA, Spentzos D, Fountzilas E, Francoeur N, Sanisetty S, Grammatikos AP, Hecht JL, Cannistra SA.
Cancer Res 71(15):5081-9. Epub 2011 Jun 15. 2011
49KEAP1, NFE2L2
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M.
Proc Natl Acad Sci U S A 107(7):2842-7. Epub 2010 Jan 27. 2010
50NFE2L2
Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis.
Schäfer M, Dütsch S, auf dem Keller U, Navid F, Schwarz A, Johnson DA, Johnson JA, Werner S.
Genes Dev 24(10):1045-58.PMID: 20478997 2010
51GADD45GIP1, NFE2L2
CR6-interacting factor 1 (CRIF1) regulates NF-E2-related factor 2 (NRF2) protein stability by proteasome-mediated degradation.
Kang HJ, Hong YB, Kim HJ, Bae I.
J Biol Chem. 285(28):21258-68 2010
52HDAC2, NFE2L2
Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction.
Adenuga D, Caito S, Yao H, Sundar IK, Hwang JW, Chung S, Rahman I.
Biochem Biophys Res Commun 403(3-4):452-6. Epub 2010 Nov 19. 2010
53CUL3, NFE2L2, RBX1
An autoregulatory loop between Nrf2 and Cul3-Rbx1 controls their cellular abundance.
Kaspar JW, Jaiswal AK.
J Biol Chem 285(28):21349-58. Epub 2010 May 7. 2010
54JUN, NFE2L2
C-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements.
Levy S, Forman HJ.
IUBMB Life. 62(3):237-46. 2010
55NFE2L2, UBE2E3
The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2.
Plafker KS, Nguyen L, Barneche M, Mirza S, Crawford D, Plafker SM.
J Biol Chem 285(30):23064-74. doi: 10.1074/jbc.M110.121913. Epub 2010 May 18. 2010
56CBR3, NFE2L2
Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells.
Ebert B, Kisiela M, Malátková P, El-Hawari Y, Maser E.
Biochemistry 49(39):8499-511. doi: 10.1021/bi100814d. Epub 2010 Sep 8. 2010
57CES1, NFE2L2
Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2).
Maruichi T, Fukami T, Nakajima M, Yokoi T.
Biochem Pharmacol 79(2):288-95. doi: 10.1016/j.bcp.2009.08.019. Epub 2009 Aug 26. 2010
58KEAP1, NFE2L2
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer.
Hayes JD, McMahon M.
Trends Biochem Sci 34(4):176-88. Epub 2009 Mar 25. Review.PMID: 19321346 2009
59NFE2L2
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response.
Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, Zhang DD.
Mol Cell. 34(6):663-73. 2009
60CUL3, KEAP1, NFE2L2
Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy.
Shibata T, Ohta T, Tong KI, Kokubu A, Odogawa R, Tsuta K, Asamura H, Yamamoto M, Hirohashi S.
Proc Natl Acad Sci U S A 105(36):13568-73. Epub 2008 Aug 29. 2008
61NFE2L1, NFE2L2
Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes.
Ohtsuji M, Katsuoka F, Kobayashi A, Aburatani H, Hayes JD, Yamamoto M.
J Biol Chem 283(48):33554-62. Epub 2008 Sep 30. 2008
62CD36, NFE2L2
Nrf2 regulates the alternative first exons of CD36 in macrophages through specific antioxidant response elements.
Maruyama A, Tsukamoto S, Nishikawa K, Yoshida A, Harada N, Motojima K, Ishii T, Nakane A, Yamamoto M, Itoh K.
Arch Biochem Biophys 477(1):139-45. Epub 2008 Jun 15. 2008
63NFE2L2
Metallothionein-III protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a PI3K and ERK/Nrf2-dependent manner.
Hwang YP, Kim HG, Han EH, Jeong HG.
Toxicol Appl Pharmacol. 231(3):318-27 2008
64NFE2L2
Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction.
Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R.
Proc Natl Acad Sci U S A. 105(7):2325-30 2008
65KEAP1, NFE2L2
A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity.
Nioi P, Nguyen T.
Biochem Biophys Res Commun 362(4):816-21. Epub 2007 Aug 27. 2007
66BACH1, NFE2L2
Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1.
Reichard JF, Motz GT, Puga A.
Nucleic Acids Res 35(21):7074-86. Epub 2007 Oct 16. 2007
67NFE2L2
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury.
Marzec JM, Christie JD, Reddy SP, Jedlicka AE, Vuong H, Lanken PN, Aplenc R, Yamamoto T, Yamamoto M, Cho HY, Kleeberger SR.
FASEB J 21(9):2237-46. Epub 2007 Mar 23. 2007
68AHR, NFE2L2
NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis.
Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, Kensler TW.
Mol Cell Biol 27(20):7188-97. Epub 2007 Aug 20.PMID: 17709388 2007
69NFE2L2, PARK7, NQO1
DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2.
Clements CM, McNally RS, Conti BJ, Mak TW, Ting JP.
Proc Natl Acad Sci U S A 103(41):15091-6. Epub 2006 Oct 2. 2006
70ABCC2, NFE2L2
Role of Nrf2 in the regulation of the Mrp2 (ABCC2) gene.
Vollrath V, Wielandt AM, Iruretagoyena M, Chianale J.
Biochem J 395(3):599-609. 2006
71KEAP1, NFE2L2
Mechanistic studies of the Nrf2-Keap1 signaling pathway.
Zhang DD.
Drug Metab Rev 38(4):769-89. Review.PMID: 17145701 2006
72NFE2L2, SMARCA4
BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress.
Zhang J, Ohta T, Maruyama A, Hosoya T, Nishikawa K, Maher JM, Shibahara S, Itoh K, Yamamoto M.
Mol Cell Biol. 26(21):7942-52. 2006
73NFE2L2
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis.
Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S.
J Clin Invest. 116(4):984-95. 2006
74CHD6, NFE2L2
The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation.
Nioi P, Nguyen T, Sherratt PJ, Pickett CB.
Mol Cell Biol 25(24):10895-906. 2005
75GSS,NFE2L2
Cloning and characterization of the human glutathione synthetase 5'-flanking region.
Lee TD, Yang H, Whang J, Lu SC.
Biochem J 390(Pt 2):521-8. 2005
76NFE2L2
Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression.
Ki SH, Cho IJ, Choi DW, Kim SG.
Mol Cell Biol. 25(10):4150-65. 2005
77NFE2L2
Identification of polymorphisms in the promoter region of the human NRF2 gene.
Yamamoto T, Yoh K, Kobayashi A, Ishii Y, Kure S, Koyama A, Sakamoto T, Sekizawa K, Motohashi H, Yamamoto M.
Biochem Biophys Res Commun 321(1):72-9. 2004
78NFE2L2
Targeted disruption of Nrf2 causes regenerative immune-mediated hemolytic anemia.
Lee JM, Chan K, Kan YW, Johnson JA.
Proc Natl Acad Sci U S A. 101(26):9751-6. 2004
79NFE2L2
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice.
Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S.
J Clin Invest. 114(9):1248-59. 2004
80NFE2L2
Nrf2 deficiency causes tooth decolourization due to iron transport disorder in enamel organ.
Yanagawa T, Itoh K, Uwayama J, Shibata Y, Yamaguchi A, Sano T, Ishii T, Yoshida H, Yamamoto M.
Genes Cells. 9(7):641-51. 2004
81NFE2L2
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival.
Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA.
Mol Cell Biol. 23(20):7198-209. 2003
82KEAP1, NFE2L2
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm.
Zipper LM, Mulcahy RT.
J Biol Chem 277(39):36544-52. Epub 2002 Jul 26.PMID: 12145307 2002
83NFE2L2
Polyamine-modulated factor 1 binds to the human homologue of the 7a subunit of the Arabidopsis COP9 signalosome: implications in gene expression.
Wang Y, Devereux W, Stewart TM, Casero RA Jr.
Biochem J. 366(Pt 1):79-86. 2002
84NFE2L2
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription.
Huang HC, Nguyen T, Pickett CB.
J Biol Chem. 277(45):42769-74. 2002
85ATF4, NFE2L2
Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation.
He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, Alam J.
J Biol Chem 276(24):20858-65. 2001
86NFE2L2
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription.
Katoh Y, Itoh K, Yoshida E, Miyagishi M, Fukamizu A, Yamamoto M.
Genes Cells. 6(10):857-68. 2001
87NFE2L2
Characterization of the interaction between the transcription factors human polyamine modulated factor (PMF-1) and NF-E2-related factor 2 (Nrf-2) in the transcriptional regulation of the spermidine/spermine N1-acetyltransferase (SSAT) gene.
Wang Y, Devereux W, Stewart TM, Casero RA Jr.
Biochem J. 355(Pt 1):45-9. 2001
88NFE2L2
An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen.
Chan K, Han XD, Kan YW.
Proc Natl Acad Sci U S A. 98(8):4611-6 2001
89NFE2L2
Transcriptional regulation of the antioxidant response element. Activation by Nrf2 and repression by MafK.
Nguyen T, Huang HC, Pickett CB.
J Biol Chem. 275(20):15466-73. 2000
90NFE2L2
Ikeda Y, Sugawara A, Taniyama Y, Uruno A, Igarashi K, Arima S, Ito S, Takeuchi K.
J Biol Chem. 275(42):33142-50. 2000
91JUN, NFE2L1, NFE2L2
Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes.
Venugopal R, Jaiswal AK.
Oncogene. 17(24):3145-56. 1998
92NFE2, NFE2L1, NFE2L2
Chromosomal localization of the human NF-E2 family of bZiP transcription factors by fluorescence in situ hybridization.
Chan JY, et al.
Hum Genet 95 : 265-269. 1995