| protein
| c-Jun, Jun-B and Jun-D  |
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antioxidant response element, ARE and v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian), MAFK |
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regulates both baseline and inducible expression of a battery of antioxidant and phase II detoxification enzymes |
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peroxisome proliferator-activated receptor gamma, PPARgamma |
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polyamine modulated factor-1, PMF-1 |
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activating transcription factor 4, ATF4 |
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CREB (cAMP Responsive Element Binding protein) Binding Protein, CBP |
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Polyamine-modulated factor 1, PMF-1 and COP9 signalosome subunit 7a, CSN 7 |
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MafF |
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kelch-like ECH-associated protein 1, KEAP1 |
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Glucocorticoid receptor, GR |
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chromodomain helicase DNA binding protein 6, CDH6 |
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transcription activator BRG1 |
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p21(Cip1/WAF1) |
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c-Myc |
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CR6-interacting factor 1, CRIF1 |
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HDAC2 |
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TRIM28 |
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KRAS and MYC |
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AMER1 and NFE2L2 compete for binding to KEAP1, and thus loss of AMER1 leads to rapid ubiquitination and degradation of NFE2L2 and a reduced response to cytotoxic insult |
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PALB2 regulates the rate of NFE2L2 export from the nucleus following induction |
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CBR3 is a target gene of NFE2L2, a cellular sensor of oxidative stress |
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antioxidant function of PARK7 by increasing TXN expression via NFE2L2-mediated transcriptional induction |
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is an important factor in upregulating TXN expression under stress conditions |
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BTG2 is a binding partner for NFE2L2 and increases its transcriptional activity |
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KEAP1 targets and binds to NFE2L2 for proteosomal degradation |
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under unstressed conditions, serves as an adaptor for ubiquitin E3 ligase and promotes proteasomal degradation of NFE2L2, but NFE2L2 is stabilized when KEAP1 is inactivated under oxidative/electrophilic stress conditions |
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MAPK7 interacts with NFE2L2 to induce its nuclear translocation and transcriptional activity |
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AMER1, PALB2, and SQSTM1 bind KEAP1 to activate NFE2L2 |
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RXRA interacts physically with NFE2L2 in cancer cells (RXRA diminishes cytoprotection by NFE2L2 by binding directly to the newly defined Neh7 domain in NFE2L2) |
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overexpression of NFE2L2 suppressed THOC1 promoter activity in an ARE-dependent manner |
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USP15 negatively regulates NFE2L2 through deubiquitination of KEAP1 |
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JDP2 associates with NFE2L2 and MAFK (NFE2L2-MAFK) to increase the transcription of antioxidant response element-dependent genes |
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JDP2 bound directly to the ARE core sequence, associated with NFE2L2 and MAFK (NFE2L2-MAFK) via basic leucine zipper domains, and increased DNA-binding activity of the NFE2L2-MAFK complex to the ARE and the transcription of ARE-dependent genes |
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CYB5R3 is an essential gene that appears as a final effector for both nutritional and oxidative stress responses through FOXO3 and NFE2L2, respectively, and their interaction promotes CYB5R3 expression |
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HACE1 plays a role in the NFE2L2 antioxidative stress response pathway and in neurodegeneration |
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in oxidative stress, nuclear HMOX1 interacts with NFE2L2 and stabilizes it from GSK3B-mediated phosphorylation coupled with ubiquitin-proteasomal degradation |
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AXIN1 and NFE2L2 physically associated in a protein complex that was regulated by WNT3A, involving the central region of AXIN1 and the Neh4/Neh5 domains of NFE2L2 |
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CACUL1/CAC1 is a positive regulator of the NFE2L2 pathway |
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NFE2L2 may be a crucial regulator that mediates PBK/TOPK-exerted promotion of cell proliferation |
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HAMP regulation is inextricably linked to the acute stress response through NFE2L2 signaling |
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low expression of HOTAIR in the spermatozoa of patients with asthenozoospermia and oligoasthenozoospermia, which resulted in down-regulation of NFE2L2 expression |
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. role of ALDOA in pancreatic cancer might attribute to its regulation of MYC, HIF1A and NFE2L2 (Nuclear Factor, Erythroid 2-Like 2), which were key regulators of glycolysis and antioxidant response control |
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PSMD10 interact with the Kelch domain of KEAP1 and effectively competed with NFE2L2 for KEAP1 binding |
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directly IL36G stimulates proliferation of keratinocytes, and it induces expression of keratinocyte mitogens in fibroblasts, suggesting that the NFE2L2-IL36G axis promotes keratinocyte proliferation through a double paracrine loop |
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in addition to regulating NFE2L2, RCBTB1 might exert other functions |
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SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2-related factor 2 (NFE2L2) on lysines 506 and 508, leading to a reduction in total and nuclear NFE2L2 levels |
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depletion of NFE2L2 or PGAM5, but not KEAP1, inhibits mitochondrial retrograde trafficking induced by proteasome inhibition |
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NFE2L2 is required to adapt the levels of SLC38A3 in response to metabolic acidosis |
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FGF19 induced an antioxidant response through stimulating the expression of nuclear erythroid factor 2 NFE2L2 and as well as reducing ROS production through the AMPK signaling pathway |
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NIBAN2 induces NFE2L2 by competing for Kelch-like ECH-associated protein 1 (KEAP1) binding (the negative regulator of NFE2L2) via an ETGE motif |
