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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

CCR5

contributors: mct - updated : 29-05-2020

HGNC name	chemokine (C-C motif) receptor 5
HGNC id	1606

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

to AIDS lymphoma to HIV disease progression, resistance or non progressive infections to West Nile virus (Omim 610379) to juvenile idiopathic arthritis (JIA) to multiple sclerosis (MS)

Variant & Polymorphism other	reduced risk of AIDS lymphoma with the CCR5-delta 32 mutation
	CCR5Delta32 is a functional variant, significantly associated with protection from developing JIA
	CCR5 delta32 mutation can be considered as a risk factor for MS

Candidate gene
Marker	CCR5 and CCL5 are potential markers for metastatic Pancreatic cancer (PC) cancer
Therapy target
	System Type Disorder Pubmed cancer digestive stomach therapeutic strategies to inhibit the CCL5/CCR5 axis in different ways in the treatment of Gastric cancer cancer skin   novel strategies of melanoma treatment could be based on blocking CCR5/CCR5 ligand interactions cancer digestive pancreas blocking CCR5/CCL5 axis might prove beneficial to prevent metastasis and provide a more therapeutic strategy to control PC progression immunology infectious   targeting CCR5 might represent a therapeutic strategy for dengue fever

ANIMAL & CELL MODELS