Citations for
Oligomeric structure of the chemokine CCL5/RANTES from NMR, MS, and SAXS data.
Wang X, Watson C, Sharp JS, Handel TM, Prestegard JH.
Structure 19(8):1138-48. 2011
Resequencing of the CCL5 and CCR5 genes and investigation of variants for association with diabetic nephropathy.
Pettigrew KA, McKnight AJ, Patterson CC, Kilner J, Sadlier DM, Maxwell AP.
J Hum Genet 55(4):248-51. Epub 2010 Mar 5. 2010
Association of the CCR5 gene with juvenile idiopathic arthritis.
Hinks A, Martin P, Flynn E, Eyre S, Packham J; Childhood Arthritis Prospective Study (CAPS), UKRAG Consortium, BSPAR Study Group, Barton A, Worthington J, Thomson W.
Genes Immun enes Immun. 2010 May 13. [Epub ahead of print]PMID: 20463745 2010
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC.
Science 330(6007):1066-71. Epub 2010 Oct 7. 2010
5CCR5, CD4
CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.
Achour L, Scott MG, Shirvani H, Thuret A, Bismuth G, Labbé-Jullié C, Marullo S.
Blood 113(9):1938-47. Epub 2008 Dec 8.PMID: 19064722 2009
An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.
Cheung R, Malik M, Ravyn V, Tomkowicz B, Ptasznik A, Collman RG.
J Leukoc Biol 86(4):833-45. Epub 2009 Jul 20.PMID: 19620252 2009
CCL5/CCR5 axis promotes the motility of human oral cancer cells.
Chuang JY, Yang WH, Chen HT, Huang CY, Tan TW, Lin YT, Hsu CJ, Fong YC, Tang CH.
J Cell Physiol 220(2):418-26. 2009
CXCR4-CCR5: a couple modulating T cell functions.
Contento RL, Molon B, Boularan C, Pozzan T, Manes S, Marullo S, Viola A.
Proc Natl Acad Sci U S A 105(29):10101-6. Epub 2008 Jul 15. 2008
CCL3L1-CCR5 genotype improves the assessment of AIDS Risk in HIV-1-infected individuals.
Kulkarni H, Agan BK, Marconi VC, O'Connell RJ, Camargo JF, He W, Delmar J, Phelps KR, Crawford G, Clark RA, Dolan MJ, Ahuja SK.
PLoS One 3(9):e3165. 2008
10CCL3L1, CCR5
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals.
Ahuja SK, Kulkarni H, Catano G, Agan BK, Camargo JF, He W, O'Connell RJ, Marconi VC, Delmar J, Eron J, Clark RA, Frost S, Martin J, Ahuja SS, Deeks SG, Little S, Richman D, Hecht FM, Dolan MJ.
Nat Med 14(4):413-20. Epub 2008 Mar 30. 2008
11CCL3, CCR5
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process.
Wu Y, Li YY, Matsushima K, Baba T, Mukaida N.
J Immunol 181(9):6384-93.PMID: 18941229 2008
The duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization.
Chakera A, Seeber RM, John AE, Eidne KA, Greaves DR.
Mol Pharmacol 73(5):1362-70. Epub 2008 Jan 29. 2008
Lack of association between the chemokine receptor 5 polymorphism CCR5delta32 in rheumatoid arthritis and juvenile idiopathic arthritis.
Lindner E, Nordang GB, Melum E, Flatø B, Selvaag AM, Thorsby E, Kvien TK, Førre OT, Lie BA.
BMC Med Genet 8:33.PMID: 17565662 2007
14CCR5, CCL5
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.
Tyner JW, Uchida O, Kajiwara N, Kim EY, Patel AC, O'sullivan MP, Walter MJ, Schwendener RA, Cook DN, Danoff TM, Holtzman MJ.
Nat Med 11(11):1180-7. Epub 2005 Oct 2. 2005
JM4 is a four-transmembrane protein binding to the CCR5 receptor.
Schweneker M, Bachmann AS, Moelling K.
FEBS Lett 579(7):1751-8. 2005
16CCL26, CCR1, CCR2, CCR5
Eotaxin-3/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with a regulatory role.
Petkovic V, Moghini C, Paoletti S, Uguccioni M, Gerber B.
J Biol Chem 279(22):23357-63. Epub 2004 Mar 23. 2004
17CCR5, CD4, IL10, IL4
Regulation of CC chemokine receptor 5 and CD4 expression and human immunodeficiency virus type 1 replication in human macrophages and microglia by T helper type 2 cytokines.
Wang J, Crawford K, Yuan M, Wang H, Gorry PR, Gabuzda D.
J Infect Dis 185(7):885-97. 2002
Prevalence of the CCR5Delta32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection.
Grimaldi R, Shindo N, Acosta X, Dourado I, Brites C, De Melo Carvalho O, Brito I, Bou-Habib C, Galvao-Castro B.
Hum Genet 111(1):102-4. 2002
Chemokine receptor CCR5: polymorphism at protein level.
Suzuki S, Miyagi T, Chuang LF, Yau PM, Doi RH, Chuang RY.
Biochem Biophys Res Commun 296(2):477-483. 2002
Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.
Seibert C, Cadene M, Sanfiz A, Chait BT, Sakmar TP.
Proc Natl Acad Sci U S A 99(17):11031-6. Epub 2002 Aug 8. 2002
Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence.
Seibert C, Cadene M, Sanfiz A, Chait BT, Sakmar TP.
Proc Natl Acad Sci U S A 99(17):11031-6. Epub 2002 Aug 8. 2002
Five-transmembrane domains appear sufficient for a G protein-coupled receptor: functional five-transmembrane domain chemokine receptors.
Ling K, et al.
Proc Natl Acad Sci U S A 96(14):7922-7. 1999
Intracellular signalling pathways induced by chemokines in natural killer cells.
Maghazachi AA.
Cell Signal 11(6):385-90. Review 1999
Reduced risk of AIDS lymphoma in individuals heterozygous for the CCR5-delta32 mutation.
Dean M, Jacobson LP, McFarlane G, Margolick JB, Jenkins FJ, Howard OM, Dong HF, Goedert JJ, Buchbinder S, Gomperts E, Vlahov D, Oppenheim JJ, O'Brien SJ, Carrington M.
Cancer Res 59(15):3561-4 1999
Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences.
Carrington M, Dean M, Martin MP, O'Brien SJ.
Hum Mol Genet 8(10):1939-45 1999
A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors.
Yang Y, Kiss H, Kost-Alimova M, Kedra D, Fransson I, Seroussi E, Li J, Szeles A, Kholodnyuk I, Imreh MP, Fodor K, Hadlaczky G, Klein G, Dumanski JP, Imreh S.
Genomics 62(2):147-55. 1999
Mutational analysis of the CCR5 and CXCR4 genes (HIV-1 co-receptors) in resistance to HIV-1 infection and AIDS development among intravenous drug users.
Alvarez V, et al.
Hum Genet 102 : 483-486. 1998
Distribution of CCR5-delta 32 gene deletion across the Russian part of Eurasia.
Yudin NS, et al.
Hum Genet 102 : 695-698. 1998
Genetic accelaration of AIDS progression by a promoter variant of CCR5.
Martin MP, et al.
Science 282 : 1907-1911. 1998
The human CC chemokine receptor 5 (CCR5) gene. Multiple transcripts with 5'-end heterogeneity, dual promoter usage, and evidence for polymorphisms within the regulatory regions and noncoding exons.
Mummidi S, Ahuja SS, McDaniel BL, Ahuja SK.
J Biol Chem 272(49):30662-71. 1997
Novel alleles of the chemokine-receptor gene CCR5.
Carrington M, Kissner T, Gerrard B, Ivanov S, O'Brien SJ, Dean M.
Am J Hum Genet 61(6):1261-7. 1997
32CCR1, CCR2, CCR3, CCR4, CCR5
The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3.
Samson M, et al.
Genomics 36 : 522-526. 1996
Identification of a major co-receptor for primary isolates of HIV-1.
Deng H, et al.
Nature 381 : 661-666. 1996
HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.
Dragic T, et al.
Nature 381 : 667-673. 1996
35CCR2, CCR3, CCR5
Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
Raport CJ, et al.
J Biol Chem 271 : 17161-17166. 1996