basic FUNCTION
| mediating macrophage-tropic strains of HIV-1 entry in CD4+ T lymphocytes |
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during human T cell activation by antigen-presenting cells, recruited into the immunological synapse, where they deliver costimulatory signals |
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important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction |
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CXCR4 and the related CCR5 serve as co-receptors for HIV-1 viral particles, facilitating their entry into cells |
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is a novel link between obesity, adipose tissue inflammation, and insulin resistance |
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acts as the principal coreceptor during HIV-1 transmission and early stages of infection |
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is the major coreceptor for human immunodeficiency virus (HIV) |
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CCR5 is a host factor required for Dengue virus (DENV-2) replication in human macrophages |
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plays an important role in neuroplasticity, learning and memory, and CCR5 has a role in the cognitive deficits caused by HIV |
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critical role for CCR5 not only in the recruitment but also in the activation of myeloid-derived suppressor cells (MDSCs) in tumor lesions |
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is a critical molecule for Treg-mediated blood-brain barrier protection and a potential target to optimize Treg therapy for stroke |
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governs DNA damage repair and breast cancer stem cell expansion |
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CCR5 was required for maintenance of the mesenchymal phenotype of metastatic melanoma cells |
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critical role of CCR5 expressed by melanoma cells in cancer progression |
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is a chemokine receptor that is not expressed on neutrophils and inflammatory monocytes under homeostatic conditions |
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CCR5 plays an important role for the migration of the inflammatory monocytes to infection focus during sepsis, having protective role in sepsis |
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CCR2 and CCR5 are required for collaboration between macrophages and pulmonary-artery smooth muscle cells (PASMCs) to initiate and amplify PASMC migration and proliferation during pulmonary arterial hypertension (PAH) development |
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expression levels of CCR1, CCR5 were higher in bone marrow mast cell progenitors (MCp) than in the peripheral blood, suggesting that CCR1 and CCR5 may mediate retention in the bone marrow |
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is a pivotal regulator of macrophage trafficking in the kidneys in response to an inflammatory cascade |