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| mice deficient in CCR3 have a significant 7-fold reduction in the basal eosinophil content of the small intestine, concurrent with a 6-fold increase in the spleen ( | |
Eosinophils and the eosinophil product major basic protein were absent from the skin of sham and OVA-sensitized CCR3(-/-) mice and recruitment of eosinophils to lung parenchyma and bronchoalveolar lavage fluid was severely impaired in these mice ( |
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eosinophil trafficking to the heart in eosinophilic myocarditis depends on the chemokine receptor Ccr3 and expression of its ligands Ccl11, Ccl24, and Ccl26 in the heart in a mouse model and in patients with eosinophilic myocarditis |