| Symbol
| CCR3
| contributors: mct/npt/shn - updated : 02-05-2017
|
| HGNC name
| chemokine (C-C motif) receptor 3
|
| HGNC id
| 1604
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --over
|
| |
in bullous pemphigoid | | constitutional
|
|
| --other
|
| |
specifically expressed in choroidal neovascular endothelial cells in Age-related macular degeneration (AMD) (Takeda (2009) | | constitutional
|
|
| --low
|
|
in narcolepsy  | | constitutional
|
|
| --low
|
| |
in narcolepsy | |
| Susceptibility
|
to Kawasaki disease (KD) |
| Variant & Polymorphism
SNP
| two haplotypes of the CCR3-CCR2-CCR5 gene-cluster appear to be at risk haplotypes for KD and one a protective haplotype (Breunis 2007) |
| 
|
Candidate gene
Marker
| Therapy target
| post-transcriptional regulation of CCR3 receptors may be a potential therapeutic approach for interrupting proinflammatory signaling (Taka 2008) | |
|
| System | Type | Disorder | Pubmed |
|---|
| osteoarticular | bone | ostéoporosis | |
| CCL11/CCR3 pathway could be a new target for treatment of inflammatory bone resorption | | neurosensorial | visual | | |
| CCR3 targeting might reduce vision loss due to AMD through early detection and therapeutic angioinhibition (its activation is essential for angiogenesis in the most widely used preclinical model of neovascular AMD) |
| | |
|
| mice deficient in CCR3 have a significant 7-fold reduction in the basal eosinophil content of the small intestine, concurrent with a 6-fold increase in the spleen ( | |
Eosinophils and the eosinophil product major basic protein were absent from the skin of sham and OVA-sensitized CCR3(-/-) mice and recruitment of eosinophils to lung parenchyma and bronchoalveolar lavage fluid was severely impaired in these mice ( |
|
eosinophil trafficking to the heart in eosinophilic myocarditis depends on the chemokine receptor Ccr3 and expression of its ligands Ccl11, Ccl24, and Ccl26 in the heart in a mouse model and in patients with eosinophilic myocarditis |