Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CCR2 contributors: mct - updated : 25-04-2016
HGNC name chemokine (C-C motif) receptor 2
HGNC id 1603
ANIMAL & CELL MODELS
  • Ccr2 deficiency accelerates early disease progression and markedly impairs microglial accumulation in a transgenic mouse model of Alzheimer disease (Tg2576)
  • locomotor sensitization is significantly reduced in CCR2(-/-) mice as well as the dopamine transporter regulation and the cocaine-induced p-ERK striatal activation
  • mice with CCR2 deficiency are protected from insulin resistance but only after long periods of high-fat diet (HFD) feeding, despite the virtual absence of circulating inflammatory monocytes
  • mice that lack Ccr2 developed mechanical allodynia, but this started to resolve from 8 wk onwards