| 1 | CCR2, CCR5
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| CCR2/CCR5-mediated macrophage-smooth muscle cell crosstalk in pulmonary hypertension.
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| Abid S, Marcos E, Parpaleix A, Amsellem V, Breau M, Houssaini A, Vienney N, Lefevre M, Derumeaux G, Evans S, Hubeau C, Delcroix M, Quarck R, Adnot S, Lipskaia L.
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| Eur Respir J. Oct 10;54(4):1802308. doi: 10.1183/13993003.02308-2018. Print 2019 Oct 2019
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| 2 | CCR1, CCR2
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| Expression of the chemokine receptors CCR1 and CCR2B is up-regulated in peripheral blood B cells upon EBV infection and in established lymphoblastoid cell lines.
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| Kholodnyuk I, Rudevica Z, Leonciks A, Ehlin-Henriksson B, Kashuba E.
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| Virology 512:1-7. doi: 10.1016/j.virol.2017.08.034. Epub 2017 Sep 9.
2017
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| 3 | CCR2, CCR5, NUP85
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| Identification and Preparation of a Novel Chemokine Receptor-Binding Domain in the Cytoplasmic Regulator FROUNT
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| Sonoda A, Yoshinaga S, Yunoki K, Ezaki S, Yano K, Takeda M, Toda E, Terashima Y, Matsushima K, Terasawa H
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| Mol Biotechnol. May;59(4-5):141-150. doi: 10.1007/s12033-017-0002-2. 2017
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| 4 | CCR2, CD180
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| RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner.
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| Wezel A, van der Velden D, Maassen JM, Lagraauw HM, de Vries MR, Karper JC, Kuiper J, Bot I, Quax PH.
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| Atherosclerosis 238(1):132-9. doi: 10.1016/j.atherosclerosis.2014.11.020. Epub 2014 Nov 22.
2015
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| 5 | CCR2, CCR5, NUP85
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| Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR5.
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| Toda E, Terashima Y, Esaki K, Yoshinaga S, Sugihara M, Kofuku Y, Shimada I, Suwa M, Kanegasaki S, Terasawa H, Matsushima K.
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| Biochem J. Jan 15;457(2):313-22. doi: 10.1042/BJ20130827 2014
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| 6 | CCL2, CCR2
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| Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases.
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| Bose S, Cho J.
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| Arch Pharm Res 36(9):1039-50. doi: 10.1007/s12272-013-0161-z. Epub 2013 Jun 15. Review.
2013
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| 7 | CCR2
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| CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis.
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| Miller RE, Tran PB, Das R, Ghoreishi-Haack N, Ren D, Miller RJ, Malfait AM.
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| Proc Natl Acad Sci U S A 109(50):20602-7. doi: 10.1073/pnas.1209294110. Epub 2012 Nov 26.
2012
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| 8 | CCR2, CX3CR1
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| Arteriolar and venular remodeling are differentially regulated by bone marrow-derived cell-specific CX3CR1 and CCR2 expression.
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| Meisner JK, Song J, Price RJ.
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| PLoS One 7(9):e46312. doi: 10.1371/journal.pone.0046312. Epub 2012 Sep 24.
2012
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| 9 | CCR2
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| Knockout of ccr2 alleviates photoreceptor cell death in a model of retinitis pigmentosa.
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| Guo C, Otani A, Oishi A, Kojima H, Makiyama Y, Nakagawa S, Yoshimura N.
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| Exp Eye Res 104:39-47. doi: 10.1016/j.exer.2012.08.013. Epub 2012 Sep 26.
2012
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| 10 | CCL2, CCR2
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| MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes.
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| Hodge DL, Reynolds D, Cerbán FM, Correa SG, Baez NS, Young HA, Rodriguez-Galan MC.
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| Eur J Immunol 42(10):2644-54. doi: 10.1002/eji.201242408. Epub 2012 Aug 15.
2012
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| 11 | CCL2, CCR2
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| Chemokine CCL2 and its receptor CCR2 in the medullary dorsal horn are involved in trigeminal neuropathic pain.
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| Zhang ZJ, Dong YL, Lu Y, Cao S, Zhao ZQ, Gao YJ.
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| J Neuroinflammation 9:136. doi: 10.1186/1742-2094-9-136.
2012
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| 12 | CCL2, CCR2
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| CCR2 acts as scavenger for CCL2 during monocyte chemotaxis.
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| Volpe S, Cameroni E, Moepps B, Thelen S, Apuzzo T, Thelen M.
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| PLoS One 7(5):e37208. doi: 10.1371/journal.pone.0037208. Epub 2012 May 17.
2012
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| 13 | CCR2
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| CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair.
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| Willenborg S, Lucas T, van Loo G, Knipper JA, Krieg T, Haase I, Brachvogel B, Hammerschmidt M, Nagy A, Ferrara N, Pasparakis M, Eming SA.
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| Blood 120(3):613-25. doi: 10.1182/blood-2012-01-403386. Epub 2012 May 10.
2012
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| 14 | ACKR2, CCL2, CCR2
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| CCL2 binding is CCR2 independent in primary adult human astrocytes.
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| Fouillet A, Mawson J, Suliman O, Sharrack B, Romero IA, Woodroofe MN.
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| Brain Res 1437:115-26. doi: 10.1016/j.brainres.2011.11.049. Epub 2011 Dec 4.
2012
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| 15 | CCL2, CCR2
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| CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury.
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| Van Steenwinckel J, Reaux-Le Goazigo A, Pommier B, Mauborgne A, Dansereau MA, Kitabgi P, Sarret P, Pohl M, Mélik Parsadaniantz S.
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| J Neurosci 31(15):5865-75.
2011
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| 16 | CCR2
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| CCR2 mediates the uptake of bone marrow-derived fibroblast precursors in angiotensin II-induced cardiac fibrosis.
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| Xu J, Lin SC, Chen J, Miao Y, Taffet GE, Entman ML, Wang Y.
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| Am J Physiol Heart Circ Physiol 301(2):H538-47. Epub 2011 May 13.
2011
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| 17 | CCR2
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| CC chemokine receptor 2 deficiency aggravates cognitive impairments and amyloid pathology in a transgenic mouse model of Alzheimer's disease.
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| Naert G, Rivest S.
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| J Neurosci 31(16):6208-20.
2011
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| 18 | CCR2
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| Implication of CCR2 chemokine receptor in cocaine-induced sensitization.
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| Trocello JM, Rostene W, Melik-Parsadaniantz S, Godefroy D, Roze E, Kitabgi P, Kuziel WA, Chalon S, Caboche J, Apartis E.
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| J Mol Neurosci 44(3):147-51. doi: 10.1007/s12031-011-9508-4. Epub 2011 Mar 22.
2011
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| 19 | CCR2
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| The role of the CCR2 gene polymorphism in abdominal aortic aneurysms.
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| Katrancioglu N, Manduz S, Karahan O, Yilmaz MB, Sezgin I, Bagci G, Berkan O.
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| Angiology 62(2):140-3.
2011
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| 20 | CCR2
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| Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
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| Lu H, Huang D, Saederup N, Charo IF, Ransohoff RM, Zhou L.
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| FASEB J 25(1):358-69. Epub 2010 Oct 1.
2011
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| 21 | CCR2
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| Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice delays improvements in insulin sensitivity.
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| Gutierrez DA, Kennedy A, Orr JS, Anderson EK, Webb CD, Gerrald WK, Hasty AH.
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| Diabetes 60(11):2820-9. doi: 10.2337/db11-0314. Epub 2011 Sep 16. Erratum in: Diabetes. 2012 May;61(5):1302-4.
2011
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| 22 | CCR2
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| Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury.
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| Awad AS, Kinsey GR, Khutsishvili K, Gao T, Bolton WK, Okusa MD.
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| Am J Physiol Renal Physiol 301(6):F1358-66. doi: 10.1152/ajprenal.00332.2011. Epub 2011 Aug 31.
2011
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| 23 | CCR2, CCR5, NUP85
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| Expression and purification of human FROUNT, a common cytosolic regulator of CCR2 and CCR5.
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| Esaki K, Terashima Y, Toda E, Yoshinaga S, Araki N, Matsushima K, Terasawa H.
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| Protein Expr Purif. May;77(1):86-91. doi: 10.1016/j.pep.2010.12.012. Epub 2010 Dec 28 2011
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| 24 | CCL2, CCR2
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| The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases.
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| Conductier G, Blondeau N, Guyon A, Nahon JL, Rovère C.
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| J Neuroimmunol 224(1-2):93-100. Review.
2010
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| 25 | CCR2
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| Filamin a binds to CCR2B and regulates its internalization.
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| Minsaas L, Planagumà J, Madziva M, Krakstad BF, Masià-Balagué M, Katz AA, Aragay AM.
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| PLoS One 5(8):e12212.
2010
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| 26 | CCR2
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| Effects of the CC chemokine receptor 2 in mice deficient for the myelin protein zero (P0).
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| Oberländer M, Berghoff M.
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| Mol Cell Neurosci 45(1):59-65. Epub 2010 May 27.
2010
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| 27 | CCR2
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| CCR2 plays a critical role in dendritic cell maturation: possible role of CCL2 and NF-kappa B.
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| Jimenez F, Quinones MP, Martinez HG, Estrada CA, Clark K, Garavito E, Ibarra J, Melby PC, Ahuja SS.
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| J Immunol 184(10):5571-81. Epub 2010 Apr 19.
2010
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| 28 | CCR2
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| CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.
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| Si Y, Tsou CL, Croft K, Charo IF.
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| J Clin Invest 120(4):1192-203. doi: 10.1172/JCI40310. Epub 2010 Mar 15.
2010
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| 29 | CCL2, CCR2
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| Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone.
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| Lu Y, Chen Q, Corey E, Xie W, Fan J, Mizokami A, Zhang J.
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| Clin Exp Metastasis 26(2):161-9. Epub 2008 Nov 11.
2009
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| 30 | CCR2, CCR5, NUP85
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| FROUNT is a common regulator of CCR2 and CCR5 signaling to control directional migration.
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| Toda E, Terashima Y, Sato T, Hirose K, Kanegasaki S, Matsushima K.
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| J Immunol. Nov 15;183(10):6387-94. doi: 10.4049/jimmunol.0803469. Epub 2009 Oct 19. 2009
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| 31 | CCR2, TNPO1
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| Chemokine receptor CCR2 undergoes transportin1-dependent nuclear translocation.
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| Favre N, Camps M, Arod C, Chabert C, Rommel C, Pasquali C.
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| Proteomics 8(21):4560-76.PMID: 18846510 2008
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| 32 | CCL2,CCR2,NUP85
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| A novel activator of C-C chemokine, FROUNT, is expressed with C-C chemokine receptor 2 and its ligand in failing human heart.
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| Satoh M, Akatsu T, Ishkawa Y, Minami Y, Nakamura M.
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| J Card Fail 13(2):114-9. 2007
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| 33 | APP, CCR2
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| Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease.
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| El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD.
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| Nat Med 13(4):432-8. Epub 2007 Mar 11. 2007
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| 34 | CCL2,CCR2
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| Monocyte chemoattractant protein (MCP-1) is expressed in human cardiac cells and is differentially regulated by inflammatory mediators and hypoxia.
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| Hohensinner PJ, Kaun C, Rychli K, Ben-Tal Cohen E, Kastl SP, Demyanets S, Pfaffenberger S, Speidl WS, Rega G, Ullrich R, Maurer G, Huber K, Wojta J.
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| FEBS Lett 580(14):3532-8. Epub 2006 May 24. 2006
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| 35 | CCL2,CCR2
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| The expression of monocyte chemoattractant protein-1 and C-C chemokine receptor 2 in post-kidney transplant patients and the influence of simvastatin treatment.
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| Wang J, Zou H, Li Q, Wang Y, Xu Q.
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| Clin Chim Acta 373(1-2):44-8. Epub 2006 May 12. 2006
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| 36 | CCR2
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| CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates.
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| El-Hage N, Wu G, Ambati J, Bruce-Keller AJ, Knapp PE, Hauser KF.
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| J Neuroimmunol 178(1-2):9-16. Epub 2006 Jul 10. 2006
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| 37 | CCR2
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| Chemokine receptor CCR2 involvement in skeletal muscle regeneration.
|
| Warren GL, Hulderman T, Mishra D, Gao X, Millecchia L, O'Farrell L, Kuziel WA, Simeonova PP.
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| FASEB J 19(3):413-5. Epub 2004 Dec 15. 2005
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| 38 | CCL26, CCR1, CCR2, CCR5
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| Eotaxin-3/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with a regulatory role.
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| Petkovic V, Moghini C, Paoletti S, Uguccioni M, Gerber B.
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| J Biol Chem 279(22):23357-63. Epub 2004 Mar 23. 2004
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| 39 | CCR2
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| Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age.
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| Ortlepp JR, Vesper K, Mevissen V, Schmitz F, Janssens U, Franke A, Hanrath P, Weber C, Zerres K, Hoffmann R.
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| J Mol Med 81(6):363-7. Epub 2003 Apr 29. 2003
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| 40 | CCR2
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| Association of a Polymorphism of the CC Chemokine Receptor-2 Gene with Bone Mineral Density.
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| Yamada Y, Ando F, Niino N, Shimokata H.
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| Genomics 80(1):8-12. 2002
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| 41 | CCR2
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| Functional expression of CCR2 by human fetal astrocytes.
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| Andjelkovic AV, Song L, Dzenko KA, Cong H, Pachter JS.
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| J Neurosci Res 70(2):219-31. 2002
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| 42 | CCR2
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| CCR2A and CCR2B, the two isoforms of the monocyte chemoattractant protein-1 receptor are up-regulated and expressed by different cell subsets in idiopathic inflammatory myopathies.
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| Bartoli C, Civatte M, Pellissier JF, Figarella-Branger D.
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| Acta Neuropathol (Berl) 102(4):385-92. 2001
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| 43 | CCR2
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| The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2.
|
| Rodriguez-Frade JM, et al.
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| Proc Natl Acad Sci U S A 96(7):3628-33. 1999
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| 44 | CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CX3CR1, CXCR1, CXCR2, CXCR3, CXCR4, XCR1
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| Intracellular signalling pathways induced by chemokines in natural killer cells.
|
| Maghazachi AA.
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| Cell Signal 11(6):385-90. Review 1999
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| 45 | CCR2, CXCL12
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| Distribution of Two HIV-1-Resistant Polymorphisms (SDF1-3'A and CCR2-64I) in East Asian and World Populations and Its Implication in AIDS Epidemiology.
|
| Su B, et al.
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| Am J Hum Genet 65(4):1047-1053 1999
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| 46 | C3CER1, CCR1, CCR2, CCR3, CCR4, CCR5, LTF
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| A 1-Mb PAC contig spanning the common eliminated region 1 (CER1) in microcell hybrid-derived SCID tumors.
|
| Yang Y, Kiss H, Kost-Alimova M, Kedra D, Fransson I, Seroussi E, Li J, Szeles A, Kholodnyuk I, Imreh MP, Fodor K, Hadlaczky G, Klein G, Dumanski JP, Imreh S.
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| Genomics 62(2):147-55. 1999
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| 47 | CCR2, JAK2, CCL2
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| The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor.
|
| Mellado M, Rodriguez-Frade JM, Aragay A, del Real G, Martin AM, Vila-Coro AJ, Serrano A, Mayor F Jr, Martinez-A C.
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| J Immunol 161(2):805-13. 1998
|
| 48 | CCR1, CCR2, CCR3
|
| The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21.
|
| Daugherty BL, et al.
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| Genomics 41 : 294-295. 1997
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| 49 | CCR1, CCR2, CCR3, CCR4, CCR5
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| The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3.
|
| Samson M, et al.
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| Genomics 36 : 522-526. 1996
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| 50 | CCR2, CCR3, CCR5
|
| Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
|
| Raport CJ, et al.
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| J Biol Chem 271 : 17161-17166. 1996
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| 51 | CCR2
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| Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.
|
| Charo IF, et al.
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| Proc Natl Acad Sci U S A 91 : 2752-2756. 1994
|