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FLASH GENE

Symbol

ALG3

contributors: npt/mct - updated : 28-02-2024

HGNC name	asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)
HGNC id	23056

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005787 9 - 1550 NP_005778 50 438 - 2022 35181625 encodes the longest isoform variant 2 - - 1500 - 403 - 2022 35181625 lacks a segment in the coding region contains a shorter and distinct N-terminus supressed, mutant allele encoding a truncated protein associated with CDGID variant 3 - - 1863 - 398 - 2022 35181625 differs in the 5' UTR and the 5' coding region contains a distinct N-terminus no describe protein NM_001006941 9 - 1623 NP_001006942 44 390 - 2022 35181625 differs in the 5' UTR and the 5' coding region contains a distinct N-terminus no discribe protein

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node         Nervous brain         Reproductive female system uterus cervix       female system ovary

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	multiple membrane-spanning helices
	a C-terminal (KKXX) endoplasmic reticulum retrieval signal

HOMOLOGY

interspecies	ortholog to S.cerevisiae alg3
	ortholog to murine Alg3
	ortholog to rattus alg3_predicted

Homologene

FAMILY

ALG3 family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum

basic FUNCTION	catalysing the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol
	PPFIA1 and ALG3 may play roles in oncogene expression in in head and neck squamous cell carcinoma (HNSCC)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

glycosylation

a component

INTERACTION

DNA

RNA

small molecule

protein

HSF2 activated ALG3 and promoted the growth of breast carcinoma

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

CDG1D

related resource

Congenital Disorder of Glycosylation pages

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   expressed higher in bladder cancer than that in the normal tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential biomarker for the prognosis of Bladder Cancer
Therapy target

ANIMAL & CELL MODELS