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FLASH GENE

Symbol

SPRED2

contributors: mct - updated : 24-11-2021

HGNC name	sprouty-related, EVH1 domain containing 2
HGNC id	17722

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	loss of Spred-2 inhibits bone growth by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway
	Spred2(-/-) mice exhibit dwarfism and increase of early haematopoiesis
	Spred2-/-mice were reported to have a markedly reduced growth and shorter long bones,54 cardiac fibrosis and arrhythmias, and a shortened lifespan