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FLASH GENE

Symbol

SPRED2

contributors: mct - updated : 24-11-2021

HGNC name	sprouty-related, EVH1 domain containing 2
HGNC id	17722

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

NNL4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional       loss of function impairs autophagy, leading to cardiac dysfunction and life-threatening arrhythmias

Susceptibility

to rheumatoid arthritis (RA)

Variant & Polymorphism other	SPRED2 is an RA-susceptibility gene

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed immunology inflammatory   SPRED2 may be a new therapeutic target for the treatment of ulcerative colitis (UC)

ANIMAL & CELL MODELS

	loss of Spred-2 inhibits bone growth by inhibiting chondrocyte differentiation through up-regulation of the MAPK signaling pathway
	Spred2(-/-) mice exhibit dwarfism and increase of early haematopoiesis
	Spred2-/-mice were reported to have a markedly reduced growth and shorter long bones,54 cardiac fibrosis and arrhythmias, and a shortened lifespan