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FLASH GENE
Symbol SLC22A16 contributors: mct/npt - updated : 30-04-2010
HGNC name solute carrier family 22 (organic cation/carnitine transporter), member 16
HGNC id 20302
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve transmembrane domains
  • several sites for N-glycosylation and phosphorylation
    • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • organic cation transporter family
  • sugar transporter family
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text in the luminal membrane of epididymal epithelium and within the Sertoli cells of the testis
    basic FUNCTION
  • playing a role in the transport of carnitine in the epididymal epithelium and in the maturation of spermatozoa
  • organic cation transporter, mediator of doxorubicin uptake in cancer cells
  • involved in bleomycin-A5 uptake, as well as polyamines, (Aouida 2010)
  • may be functioning as a polyamine:l-carnitine antiporter by exporting polyamines in exchange for l-carnitine during sperm capacitation (Aouida 2010)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MAFD17
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in endometrium during the normal secretory phase, but its level was significantly reduced in the proliferative phase
    tumoral     --over  
    in endometrial cancer in the presence of progesterone
    tumoral     --over  
    in testicular cancer cells (Aouida 2010)
    Susceptibility for bipolar disorder type I
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target use progestins to increase the response of endometrioid endometrial carcinoma with SLC22A16 expression to adriamycin-based chemotherapeutic regimens
    ANIMAL & CELL MODELS