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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

SRC

contributors: mct/npt/pgu - updated : 19-06-2019

HGNC name	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)
HGNC id	11283

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

THC6

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral somatic mutation       in a small proportion of endometrial carcinoma and colon cancer tumoral   deletion     in some leukemia tumoral     --over   in some cancers constitutional     --over   results in the tyrosine phosphorylation and cytoplasmic localization of RUNX3

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive stomach RUNX3 can be relocalized in the nucleus by an SRC inhibitor, in gastric cancers, providing an additional rationale for developing SRC inhibitors as anti-cancer drugs cancer reproductive breast RUNX3 can be relocalized in the nucleus by an SRC inhibitor, in breast cancers, providing an additional rationale for developing SRC inhibitors as anti-cancer drugs immunology inflammatory   both SRC and NOS3 inhibition may be important therapeutic targets to prevent or limit vascular inflammation

ANIMAL & CELL MODELS

despite normal phosphorylation, sperm from cSrc null mice display a severe reduction in forward motility, and are unable to fertilize