| 1 | FZR1, SRC
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| Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. 2019 PMID:
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| Han T, Jiang S, Zheng H, Yin Q, Xie M, Little MR, Yin X, Chen M, Song SJ, Beg AA, Pandolfi PP, Wan L.
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| Nat Commun. Aug 16;10(1):3716. doi: 10.1038/s41467-019-11618-7. 2019
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| 2 | SRC, TLK2
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| TLK2 enhances aggressive phenotypes of glioblastoma cells through the activation of SRC signaling pathway.
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| Lin M, Yao Z, Zhao N, Zhang C.
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| Cancer Biol Ther ancer Biol Ther. 2018 Sep 12:1-8. doi: 10.1080/15384047.2018.1507257. [Epub ahead of print]
2018
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| 3 | SRC, SRCIN1
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| Overexpression of Srcin1 contributes to the growth and metastasis of colorectal cancer.
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| Zhang M, Ma F, Xie R, Wu Y, Wu M, Zhang P, Peng Y, Zhao J, Xiong J, Li A, Kequan C, Zhang Y, Liu S, Wang J, Chen X.
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| Int J Oncol 50(5):1555-1566. doi: 10.3892/ijo.2017.3952. Epub 2017 Apr 5.
2017
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| 4 | ATP1A1, SRC
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| Src Family Kinase Links Insulin Signaling to Short Term Regulation of Na,K-ATPase in Nonpigmented Ciliary Epithelium.
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| Shahidullah M, Mandal A, Delamere NA.
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| J Cell Physiol 232(6):1489-1500. doi: 10.1002/jcp.25654. Epub 2016 Nov 10.
2017
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| 5 | GNAT1, NPHP3, PKD1, SRC, UNC119
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| Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3.
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| Jaiswal M, Fansa EK, Kösling SK, Mejuch T, Waldmann H, Wittinghofer A.
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| J Biol Chem 291(39):20766-78. doi: 10.1074/jbc.M116.741827. Epub 2016 Aug 1.
2016
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| 6 | SRC, THC6
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| A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies.
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| Turro E, Greene D, Wijgaerts A, Thys C, Lentaigne C, Bariana TK, Westbury SK, Kelly AM, Selleslag D, Stephens JC, Papadia S, Simeoni I, Penkett CJ, Ashford S, Attwood A, Austin S, Bakchoul T, Collins P, Deevi SV, Favier R, Kostadima M, Lambert MP, Mathias M, Millar CM, Peerlinck K, Perry DJ, Schulman S, Whitehorn D, Wittevrongel C; BRIDGE-BPD Consortium, De Maeyer M, Rendon A, Gomez K, Erber WN, Mumford AD, Nurden P, Stirrups K, Bradley JR, Raymond FL, Laffan MA, Van Geet C, Richardson S, Freson K, Ouwehand WH.
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| Sci Transl Med 8(328):328ra30. doi: 10.1126/scitranslmed.aad7666. Epub 2016 Mar 2.
2016
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| 7 | FBLIM1, FERMT2, SRC
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| Kindlin-2 phosphorylation by Src at Y193 enhances Src activity and is involved in Migfilin recruitment to the focal adhesions.
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| Liu Z, Lu D, Wang X, Wan J, Liu C, Zhang H.
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| FEBS Lett 589(15):2001-10. doi: 10.1016/j.febslet.2015.05.038. Epub 2015 May 30.
2015
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| 8 | CTTN, NAA15, SRC
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| Tubedown regulation of retinal endothelial permeability signaling pathways.
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| Ho N, Gendron RL, Grozinger K, Whelan MA, Hicks EA, Tennakoon B, Gardiner D, Good WV, Paradis H.
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| Biol Open 4(8):970-9. doi: 10.1242/bio.010496.
2015
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| 9 | AFAP1, SRC
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| Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland.
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| Cunnick JM, Kim S, Hadsell J, Collins S, Cerra C, Reiser P, Flynn DC, Cho Y.
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| Oncogene 14;34(20):2640-9. doi: 10.1038/onc.2014.205. Epub 2014 Jul 21 2015
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| 10 | SRC
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| A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.
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| Hossain MI, Roulston CL, Kamaruddin MA, Chu PW, Ng DC, Dusting GJ, Bjorge JD, Williamson NA, Fujita DJ, Cheung SN, Chan TO, Hill AF, Cheng HC.
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| J Biol Chem 288(14):9696-709. doi: 10.1074/jbc.M112.419713. Epub 2013 Feb 11.
2013
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| 11 | ATP1A1, SRC
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| Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction.
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| Ye Q, Lai F, Banerjee M, Duan Q, Li Z, Si S, Xie Z.
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| J Biol Chem 288(8):5803-14. doi: 10.1074/jbc.M112.442608. Epub 2013 Jan 3.
2013
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| 12 | ITGB4, SRC
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| The role of c-Src in integrin (alpha6beta4) dependent translational control.
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| Soung YH, Korneeva N, Kim TH, Chung J.
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| BMC Cell Biol 14(1):49. [Epub ahead of print]
2013
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| 13 | NDUFA13, PAG1, SRC
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| GRIM-19 mutations fail to inhibit v-Src-induced oncogenesis.
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| Kalakonda S, Nallar SC, Lindner DJ, Sun P, Lorenz RR, Lamarre E, Reddy SP, Kalvakolanu DV.
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| Oncogene ncogene. 2013 Jul 15. doi: 10.1038/onc.2013.271. [Epub ahead of print]
2013
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| 14 | AURKB, KIF23, SRC
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| v-Src causes delocalization of Mklp1, Aurora B, and INCENP from the spindle midzone during cytokinesis failure.
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| Soeda S, Nakayama Y, Honda T, Aoki A, Tamura N, Abe K, Fukumoto Y, Yamaguchi N.
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| Exp Cell Res 319(10):1382-97. doi: 10.1016/j.yexcr.2013.02.023.
2013
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| 15 | ING1, SRC
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| Src regulates the activity of the ING1 tumor suppressor.
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| Yu L, Thakur S, Leong-Quong RY, Suzuki K, Pang A, Bjorge JD, Riabowol K, Fujita DJ.
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| PLoS One 8(4):e60943. doi: 10.1371/journal.pone.0060943. Print 2013.
2013
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| 16 | SRC
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| cSrc is necessary for epididymal development and is incorporated into sperm during epididymal transit.
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| Krapf D, Ruan YC, Wertheimer EV, Battistone MA, Pawlak JB, Sanjay A, Pilder SH, Cuasnicu P, Breton S, Visconti PE.
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| Dev Biol 369(1):43-53. doi: 10.1016/j.ydbio.2012.06.017. Epub 2012 Jun 30.
2012
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| 17 | SRC
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| c-Src but not Fyn promotes proper spindle orientation in early prometaphase.
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| Nakayama Y, Matsui Y, Takeda Y, Okamoto M, Abe K, Fukumoto Y, Yamaguchi N.
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| J Biol Chem 287(30):24905-15. doi: 10.1074/jbc.M112.341578. Epub 2012 Jun 11.
2012
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| 18 | SRC
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| c-Src links a RANK/αvβ3 integrin complex to the osteoclast cytoskeleton.
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| Izawa T, Zou W, Chappel JC, Ashley JW, Feng X, Teitelbaum SL.
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| Mol Cell Biol 32(14):2943-53. doi: 10.1128/MCB.00077-12. Epub 2012 May 21.
2012
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| 19 | SRC
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| EMT phenotype is induced by increased Src kinase activity via Src-mediated caspase-8 phosphorylation.
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| Zhao Y, Li X, Sun X, Zhang Y, Ren H.
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| Cell Physiol Biochem 29(3-4):341-52. doi: 10.1159/000338489. Epub 2012 Apr 3.
2012
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| 20 | SRC
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| Preservation of NADH ubiquinone-oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10.
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| Hebert-Chatelain E, Jose C, Gutierrez Cortes N, Dupuy JW, Rocher C, Dachary-Prigent J, Letellier T.
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| Biochim Biophys Acta 1817(5):718-25. doi: 10.1016/j.bbabio.2012.01.014. Epub 2012 Feb 1.
2012
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| 21 | IGFBP5, IL6, SRC
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| c-Src and IL-6 inhibit osteoblast differentiation and integrate IGFBP5 signalling.
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| Peruzzi B, Cappariello A, Del Fattore A, Rucci N, De Benedetti F, Teti A.
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| Nat Commun 3:630. doi: 10.1038/ncomms1651.
2012
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| 22 | NOS3, SRC
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| ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration.
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| Liu G, Place AT, Chen Z, Brovkovych VM, Vogel SM, Muller WA, Skidgel RA, Malik AB, Minshall RD.
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| Blood 120(9):1942-52. doi: 10.1182/blood-2011-12-397430. Epub 2012 Jul 17.
2012
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| 23 | FURIN, NOTCH1, SRC
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| The tyrosine kinase c-Src directly mediates growth factor-induced Notch-1 and Furin interaction and Notch-1 activation in pancreatic cancer cells.
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| Ma YC, Shi C, Zhang YN, Wang LG, Liu H, Jia HT, Zhang YX, Sarkar FH, Wang ZS.
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| PLoS One 7(3):e33414. doi: 10.1371/journal.pone.0033414. Epub 2012 Mar 30.
2012
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| 24 | FURIN, SRC
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| The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells.
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| Shi C, Ma Y, Liu H, Zhang Y, Wang Z, Jia H.
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| Mol Cell Biochem 362(1-2):65-70. doi: 10.1007/s11010-011-1128-3. Epub 2011 Oct 25.
2012
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| 25 | CAV1, PAG1, SRC
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| Cooperative role of caveolin-1 and C-terminal Src kinase binding protein in C-terminal Src kinase-mediated negative regulation of c-Src.
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| Place AT, Chen Z, Bakhshi FR, Liu G, O'Bryan JP, Minshall RD.
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| Mol Pharmacol 80(4):665-72. Epub 2011 Jul 21.
2011
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| 26 | HCK, IL13, SRC
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| Hck is a key regulator of gene expression in alternatively activated human monocytes.
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| Bhattacharjee A, Pal S, Feldman GM, Cathcart MK.
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| J Biol Chem 286(42):36709-23. doi: 10.1074/jbc.M111.291492. Epub 2011 Aug 30.
2011
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| 27 | BAIAP2L1, SRC
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| Src-stimulated IRTKS phosphorylation enhances cell migration.
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| Chen G, Li T, Zhang L, Yi M, Chen F, Wang Z, Zhang X.
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| FEBS Lett 585(19):2972-8. doi: 10.1016/j.febslet.2011.08.005. Epub 2011 Aug 10.
2011
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| 28 | ARHGEF5, SRC
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| The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation.
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| Kuroiwa M, Oneyama C, Nada S, Okada M.
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| J Cell Sci 124(Pt 10):1726-38. doi: 10.1242/jcs.080291. Epub 2011 Apr 26.
2011
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| 29 | CTTN, SH3PXD2B, SRC
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| The homolog of the five SH3-domain protein (HOFI/SH3PXD2B) regulates lamellipodia formation and cell spreading.
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| Lányi Á, Baráth M, Péterfi Z, Bogel G, Orient A, Simon T, Petrovszki E, Kis-Tóth K, Sirokmány G, Rajnavölgyi É, Terhorst C, Buday L, Geiszt M.
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| PLoS One 6(8):e23653. doi: 10.1371/journal.pone.0023653.
2011
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| 30 | SH3PXD2A, SRC
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| A Src-Tks5 pathway is required for neural crest cell migration during embryonic development.
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| Murphy DA, Diaz B, Bromann PA, Tsai JH, Kawakami Y, Maurer J, Stewart RA, Izpisúa-Belmonte JC, Courtneidge SA.
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| PLoS One 6(7):e22499. doi: 10.1371/journal.pone.0022499. Erratum in: PLoS One. 2012;7(8). doi: 10.1371/annotation/d66234d8-b722-4b6d-ab8a 2011
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| 31 | BCAR1, BCAR3, SRC
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| BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling.
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| Schuh NR, Guerrero MS, Schrecengost RS, Bouton AH.
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| J Biol Chem 285(4):2309-17. Epub 2009 Nov 23.PMID: 19940159 2010
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| 32 | RUNX3, SRC
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| Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm.
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| Goh YM, Cinghu S, Hong ET, Lee YS, Kim JH, Jang JW, Li YH, Chi XZ, Lee KS, Wee H, Ito Y, Oh BC, Bae SC.
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| J Biol Chem 285(13):10122-9. Epub 2010 Jan 25. 2010
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| 33 | CA9, SRC
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| Src induces expression of carbonic anhydrase IX via hypoxia-inducible factor 1.
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| Takacova M, Holotnakova T, Barathova M, Pastorekova S, Kopacek J, Pastorek J.
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| Oncol Rep 23(3):869-74.
2010
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| 34 | CLEC1B, SRC, SYK
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| CLEC-2 activates Syk through dimerization.
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| Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP.
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| Blood 115(14):2947-55. doi: 10.1182/blood-2009-08-237834. Epub 2010 Feb 12.
2010
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| 35 | SRC
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| c-Src regulates Akt signaling in response to ghrelin via beta-arrestin signaling-independent and -dependent mechanisms.
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| Lodeiro M, Theodoropoulou M, Pardo M, Casanueva FF, Camińa JP.
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| PLoS One 4(3):e4686. Epub 2009 Mar 5.
2009
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| 36 | FYN, LYN, SRC, YES1
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| Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain.
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| Sato I, Obata Y, Kasahara K, Nakayama Y, Fukumoto Y, Yamasaki T, Yokoyama KK, Saito T, Yamaguchi N.
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| J Cell Sci 122(Pt 7):965-75. Epub 2009 Mar 3.
2009
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| 37 | SRC
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| Src activation and translocation from focal adhesions to membrane ruffles contribute to formation of new adhesion sites.
|
| Hamadi A, Deramaudt TB, Takeda K, Rondé P.
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| Cell Mol Life Sci 66(2):324-38.
2009
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| 38 | PDLIM4, PTPN13, SRC
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| Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle.
|
| Zhang Y, Tu Y, Zhao J, Chen K, Wu C.
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| J Cell Biol 184(6):785-92.PMID: 19307596 2009
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| 39 | SGK1, SRC
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| Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels.
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| Yue P, Lin DH, Pan CY, Leng Q, Giebisch G, Lifton RP, Wang WH.
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| Proc Natl Acad Sci U S A 106(35):15061-6. Epub 2009 Aug 18.PMID: 19706464 2009
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| 40 | SRC, STAT5B
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| c-Src tyrosine kinase co-associates with and phosphorylates signal transducer and activator of transcription 5b which mediates the proliferation of normal human B lymphocytes.
|
| Cayer MP, Proulx M, Ma XZ, Sakac D, Gigučre JF, Drouin M, Néron S, Branch DR, Jung D.
|
| Clin Exp Immunol 156(3):419-27.PMID: 19438593 2009
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| 41 | DVL2, SRC
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| Dishevelled-2 docks and activates Src in a Wnt-dependent manner.
|
| Yokoyama N, Malbon CC.
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| J Cell Sci 122(Pt 24):4439-51. Epub 2009 Nov 17.
2009
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| 42 | ACP1, EPHA2, SRC
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| Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.
|
| Fang WB, Ireton RC, Zhuang G, Takahashi T, Reynolds A, Chen J.
|
| J Cell Sci 121(Pt 3):358-68. Epub 2008 Jan 15. 2008
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| 43 | CD63, KCNJ1, PTPRA, SRC
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| Expression of tetraspan protein CD63 activates protein-tyrosine kinase (PTK) and enhances the PTK-induced inhibition of ROMK channels.
|
| Lin D, Kamsteeg EJ, Zhang Y, Jin Y, Sterling H, Yue P, Roos M, Duffield A, Spencer J, Caplan M, Wang WH.
|
| J Biol Chem 283(12):7674-81. Epub 2008 Jan 22. 2008
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| 44 | SDCBP, SRC
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| mda-9/Syntenin promotes metastasis in human melanoma cells by activating c-Src.
|
| Boukerche H, Su ZZ, Prévot C, Sarkar D, Fisher PB.
|
| Proc Natl Acad Sci U S A 105(41):15914-9. Epub 2008 Oct 2.
2008
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| 45 | SRC
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| Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
|
| Shindo M, Wada H, Kaido M, Tateno M, Aigaki T, Tsuda L, Hayashi S.
|
| Development 135(7):1355-64. Epub 2008 Feb 27.PMID: 18305002 2008
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| 46 | PALLD, SRC, NCKIPSD
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| Palladin interacts with SH3 domains of SPIN90 and Src and is required for Src-induced cytoskeletal remodeling.
|
| Ronty M, Taivainen A, Heiska L, Otey C, Ehler E, Song WK, Carpen O.
|
| Exp Cell Res 313(12):2575-85. Epub 2007 May 8. 2007
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| 47 | CSK, MAPK14, SRC
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| Suppression of c-Src activity stimulates muscle differentiation via p38 MAPK activation.
|
| Lim MJ, Seo YH, Choi KJ, Cho CH, Kim BS, Kim YH, Lee J, Lee H, Jung CY, Ha J, Kang I, Kim SS.
|
| Arch Biochem Biophys 465(1):197-208. Epub 2007 Jun 12. 2007
|
| 48 | SP3, SRC
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| The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter.
|
| Ellis DJ, Dehm SM, Bonham K.
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| Gene [Epub ahead of print] 2006
|
| 49 | SRC
|
| Increased Src kinase level results in increased protein tyrosine phosphorylation in scrapie-infected neuronal cell lines.
|
| Gyllberg H, Lfgren K, Lindegren H, Bedecs K.
|
| FEBS Lett 580(11):2603-8. Epub 2006 Apr 21. 2006
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| 50 | CSNK2A1, SLK, SRC
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| v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II.
|
| Chaar Z, O'reilly P, Gelman I, Sabourin LA.
|
| J Biol Chem 281(38):28193-9. Epub 2006 Jul 12.
2006
|
| 51 | FYN, SRC, YES1
|
| Src, Fyn and Yes play differential roles in VEGF-mediated endothelial cell events.
|
| Werdich XQ, Penn JS.
|
| Angiogenesis 8(4):315-26. Epub 2006 Jan 7.
2005
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| 52 | GIT2, PTK2, SRC
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| Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
|
| Brown MC, Cary LA, Jamieson JS, Cooper JA, Turner CE.
|
| Mol Biol Cell 16(9):4316-28.
2005
|
| 53 | CBLC,SRC
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| Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.
|
| Kim M, Tezuka T, Tanaka K, Yamamoto T.
|
| Oncogene 23(9):1645-55. Erratum in: Oncogene. 2004 Oct 14;23(47):7903-4. 2004
|
| 54 | SRC, YES1
|
| The Src family of tyrosine kinases is important for embryonic stem cell self-renewal.
|
| Annerén C, Cowan CA, Melton DA.
|
| J Biol Chem 279(30):31590-8. Epub 2004 May 17.
2004
|
| 55 | SRC, ADRBK1, PDE6G
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| The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor.
|
| Wan KF, Sambi BS, Tate R, Waters C, Pyne NJ.
|
| J Biol Chem 278(20):18658-63. Epub 2003 Mar 6. 2003
|
| 56 | SRC, KDELR1
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| Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum.
|
| Bard F, Mazelin L, Pechoux-Longin C, Malhotra V, Jurdic P.
|
| J Biol Chem 278(47):46601-6. Epub 2003 Sep 15. 2003
|
| 57 | HCK, SRC
|
| Src tyrosine kinase is a novel direct effector of G proteins.
|
| Ma YC, Huang J, Ali S, Lowry W, Huang XY.
|
| Cell 102(5):635-46. 2000
|
| 58 | SRC
|
| Mutation of the SRC gene in endometrial carcinoma.
|
| Sugimura M, Kobayashi K, Sagae S, Nishioka Y, Ishioka S, Terasawa K, Tokino T, Kudo R.
|
| Jpn J Cancer Res 91(4):395-8. 2000
|
| 59 | SRC
|
| An alternative, human SRC promoter and its regulation by hepatic nuclear factor-1alpha.
|
| Bonham K, Ritchie SA, Dehm SM, Snyder K, Boyd FM.
|
| J Biol Chem 275(48):37604-11. 2000
|
| 60 | SRC, TNFSF11, TRAF6
|
| TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src.
|
| Wong BR, Besser D, Kim N, Arron JR, Vologodskaia M, Hanafusa H, Choi Y.
|
| Mol Cell 4(6):1041-9 1999
|
| 61 | SRC
|
| Dinucleotide repeat polymorphism in the human SRC gene on chromosome 20.
|
| Xiang K, et al.
|
| Nucleic Acids Res 19 : 6967. 1991
|
| 62 | SRC
|
| Localization of the SRC oncogene to chromosome band 20q11.2 and loss of this gene with deletion (20q) in two leukemic patients.
|
| Morris CM, et al.
|
| Blood 74 : 1768-1773. 1989
|
| 63 | FGR, SRC
|
| Isolation of duplicated human c-src genes located on chromosomes 1 and 20.
|
| Parker RC, et al.
|
| Mol Cell Biol 5 : 831-838. 1985
|
| 64 | SRC
|
| Evidence for two distinct c-src loci on human chromosomes 1 and 20.
|
| Le Beau MM, et al.
|
| Nature 312 : 70-71. 1984
|
| 65 | SRC
|
| A sequence homologous to Rous sarcoma virus v-src is on human chromosome 20.
|
| Sakaguchi AY, et al.
|
| Prog Nucleic Acid Res Mol Biol 29 : 279-283. 1983
|