| basic FUNCTION
| with PANX1 have many characteristics that are distinct from GJA1 and these proteins probably play an important biological role as single membrane channels  |
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play a role in gap junctional intercellular communication and as single-membrane channels, although many of its molecular characteristics differ from connexins (important role for pannexin glycosylation in trafficking) |
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like connexins, may play an important role in hearing |
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may have functions to switch the chondrocyte cell fate from proliferation to differentiation by regulating the intracellular ATP/cAMP levels |
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regulator of the switching mechanism behind the transition of chondrocytes from a proliferative state to a postmitotic state and that it is required for chondrocyte differentiation |
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functioned as a unique Ca(2+) channel in the endoplasmic reticulum (ER), which was activated by (PI3K)/Akt signaling, followed by activation of calmodulin signaling for differentiation |
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regulator that promotes osteoblast differentiation by functioning as an ER Ca(2+) channel and a hemichannel, and by forming gap junctions |
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PANX1 and PANX3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation status of these cells |
