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FLASH GENE
Symbol ICAM5 contributors: mct - updated : 28-10-2010
HGNC name intercellular adhesion molecule 5, telencephalin
HGNC id 5348
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal signal sequence
  • an extracellular region with nine Ig-like domains
  • a single transmembrane segment (1TM)
  • a cytoplasmic C terminus
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Icam5
    intraspecies homolog to ICAM1,ICAM3, highly
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • ICAM-family of adhesion proteins
    • CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • brain segment specific neuronal adhesion molecule
  • adhesion of growing axons to make proper synaptic connection
  • may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases
  • important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission
  • may be involved in immune privilege of the brain and acts as an anti-inflammatory agent
  • dendritically polarized membrane glycoprotein expressed in tissues distinct from those expressing other ICAMs
  • plays a critical role in modulating chemokine production in the CNS
    • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for LFA1 (lymphocyte function-associated antigen 1), a major leukocyte integ-rin expressed in lymphocytes and microglia
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in premature and ectopic development of the dendrites and synaptic network in holoprosencephaly
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS