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FLASH GENE
Symbol ICAM5 contributors: mct - updated : 28-10-2010
HGNC name intercellular adhesion molecule 5, telencephalin
HGNC id 5348
Location 19p13.2      Physical location : 10.400.654 - 10.407.452
Synonym name
  • dendrite cell adhesion molecule
  • telencephalin
  • Synonym symbol(s) TLCN, TLN, ICA5
    DNA
    TYPE functioning gene
    STRUCTURE 6.81 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3005 97.1 924 - 1998 9638475
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Nervousbrainforebrain  highly
     braindiencephalonhypothalamus  
    Reproductivefemale systemovary   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period perinatal
    Text at the time of birth
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal signal sequence
  • an extracellular region with nine Ig-like domains
  • a single transmembrane segment (1TM)
  • a cytoplasmic C terminus
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Icam5
    intraspecies homolog to ICAM1,ICAM3, highly
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • ICAM-family of adhesion proteins
  • CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • brain segment specific neuronal adhesion molecule
  • adhesion of growing axons to make proper synaptic connection
  • may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases
  • important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission
  • may be involved in immune privilege of the brain and acts as an anti-inflammatory agent
  • dendritically polarized membrane glycoprotein expressed in tissues distinct from those expressing other ICAMs
  • plays a critical role in modulating chemokine production in the CNS
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for LFA1 (lymphocyte function-associated antigen 1), a major leukocyte integ-rin expressed in lymphocytes and microglia
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in premature and ectopic development of the dendrites and synaptic network in holoprosencephaly
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS