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FLASH GENE

Symbol

ICAM5

contributors: mct - updated : 28-10-2010

HGNC name	intercellular adhesion molecule 5, telencephalin
HGNC id	5348

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.2      Physical location : 10.400.654 - 10.407.452
Synonym name	dendrite cell adhesion molecule
	telencephalin
Synonym symbol(s)	TLCN, TLN, ICA5

DNA

TYPE	functioning gene
STRUCTURE	6.81 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003259 11 - 3005 NP_003250 97.1 924 - 1998 9638475

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid         Nervous brain forebrain     highly   brain diencephalon hypothalamus     Reproductive female system ovary

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

perinatal

Text	at the time of birth

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal signal sequence
	an extracellular region with nine Ig-like domains
	a single transmembrane segment (1TM)
	a cytoplasmic C terminus

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Icam5

intraspecies

homolog to ICAM1,ICAM3, highly

Homologene

FAMILY	immunoglobulin superfamily
	ICAM-family of adhesion proteins

CATEGORY

adhesion , signaling

SUBCELLULAR LOCALIZATION	plasma membrane
text	type I transmembrane protein

basic FUNCTION	brain segment specific neuronal adhesion molecule
	adhesion of growing axons to make proper synaptic connection
	may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases
	important for the regulation of immunological activity in the brain and for the development of neuronal synapses and signal transmission
	may be involved in immune privilege of the brain and acts as an anti-inflammatory agent
	dendritically polarized membrane glycoprotein expressed in tissues distinct from those expressing other ICAMs
	plays a critical role in modulating chemokine production in the CNS

CELLULAR PROCESS

cell communication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand for LFA1 (lymphocyte function-associated antigen 1), a major leukocyte integ-rin expressed in lymphocytes and microglia

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in premature and ectopic development of the dendrites and synaptic network in holoprosencephaly

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS