| basic FUNCTION
| methylating (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain |
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acting as a restriction factor for HIV replication |
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specifically methylates the nonhistone chromatin protein HMGA1  |
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plays a role as a regulator of DNA base excision repair |
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regulate DNA repair and gene expression |
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mammalian methyltransferase for H3 R2 and a crucial negative regulator of H3 K4 trimethylation and transcriptional activation |
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functioning as a transcriptional coactivator that can also regulate alternative splicing |
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has a dual role in regulating gene expression and that these two functions can occur independently of each other |
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dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis |
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utilizes a rapid equilibrium random mechanism with dead-end EAP and EBQ complexes |
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is potentially important for ES cell pluripotency and self-renewal |
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facilitates cell proliferation and blocks senescence by regulation of tumor suppressor genes and that this might contribute to the oncogenic capacity of PRMT6 |
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methylate the HMGA1 protein in the second AT hook and likely regulates chromatin structure organization |
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regulates cell cycle progression |
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implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis |
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its overexpression is associated with regulation of motility and invasion through up-regulation of THBS1 and down-regulation of MMPs in cancer cells |
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arginine methyltransferase known to methylate AT-hook motifs, downregulating the expression of HLA-DQ, but not HLA-DR, in an AT-hook-dependent manner |
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PRMT6 is involved in the regulation of hepatic glucose metabolism in a CRTC2-dependent manner |
