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FLASH GENE
Symbol PRMT6 contributors: mct/npt/pgu - updated : 22-08-2014
HGNC name protein arginine N-methyltransferase 6
HGNC id 18241
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung    
Urinarybladder    
 kidney    
Visualeyelacrimal gland   
cells
SystemCellPubmedSpeciesStageRna symbol
Respiratoryepithelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Prmt6 (94.0pc)
Homologene
FAMILY
  • protein arginine N-methyltransferase family
  • PRMT6 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • predominantly in nucleus
  • basic FUNCTION
  • methylating (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain
  • acting as a restriction factor for HIV replication
  • specifically methylates the nonhistone chromatin protein HMGA1
  • plays a role as a regulator of DNA base excision repair
  • regulate DNA repair and gene expression
  • mammalian methyltransferase for H3 R2 and a crucial negative regulator of H3 K4 trimethylation and transcriptional activation
  • functioning as a transcriptional coactivator that can also regulate alternative splicing
  • has a dual role in regulating gene expression and that these two functions can occur independently of each other
  • dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis
  • utilizes a rapid equilibrium random mechanism with dead-end EAP and EBQ complexes
  • is potentially important for ES cell pluripotency and self-renewal
  • facilitates cell proliferation and blocks senescence by regulation of tumor suppressor genes and that this might contribute to the oncogenic capacity of PRMT6
  • methylate the HMGA1 protein in the second AT hook and likely regulates chromatin structure organization
  • regulates cell cycle progression
  • implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis
  • its overexpression is associated with regulation of motility and invasion through up-regulation of THBS1 and down-regulation of MMPs in cancer cells
  • arginine methyltransferase known to methylate AT-hook motifs, downregulating the expression of HLA-DQ, but not HLA-DR, in an AT-hook-dependent manner
  • PRMT6 is involved in the regulation of hepatic glucose metabolism in a CRTC2-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • directly regulates the THBS1 promoter activity (THBS1 is a transcriptional repression target of PRMT6)
  • regulates gene transcription via its ability to methylate histones H3 and H4
  • CDKN1A is a direct target of PRMT6 and the corresponding histone mark H3R2me2
  • HMGA1 is a substrate for PRMT6, having a modulatory role on the methyltransferase activity of PRMT6
  • negative function of PRMT6 on invasion and migration of cancer cells through up-regulation of THBS1 and down-regulation of MMP2 and MMP9
  • PELP1 interacts with the arginine methyltransferase PRMT6 and modifies PRMT6 functions
  • in cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues of CRTC2, which enhanced the association of CRTC2 with CREB on the promoters of gluconeogenic enzyme-encoding genes
  • cell & other
    REGULATION
    Other automethylation activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with regulation of motility and invasion through up-regulation of THBS1 and down-regulation of MMPs in cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS