| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --low
|
|
|
in sporadic Wilms tumor (by hypermethylation) |
| tumoral
|
|
| --low
|
|
|
in multiple human tumor type |
| tumoral
|
|
| --low
|
|
|
by hyper methylation in gastric carcinoma (Sakata 2009) |
| constitutional
|
|
| --low
|
|
associated with a significant decrease in apoptosis and an accumulation of cells in the S and G2/M phases  |
| constitutional
|
|
| --over
|
|
|
in the serum of patients with heart failure |
| constitutional
|
|
| --low
|
|
|
reduction of HACE1 levels in the striatum of Huntington disease patients, implicating HACE1 in the pathology of Huntington disease |
| tumoral
|
|
| --low
|
|
|
by hypermethylation in hepatocellular carcinoma |
