Citations for
1HACE1, RAC1
Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
Andrio E, Lotte R, Hamaoui D, Cherfils J, Doye A, Daugaard M, Sorensen PH, Bost F, Ruimy R, Mettouchi A, Lemichez E.
Sci Rep 7:44779. doi: 10.1038/srep44779. 2017
2HACE1
Tumor-suppressive role of HACE1 in hepatocellular carcinoma and its clinical significance.
Gao ZF, Wu YN, Bai ZT, Zhang L, Zhou Q, Li X.
Oncol Rep 36(6):3427-3435. doi: 10.3892/or.2016.5205. Epub 2016 Oct 26. 2016
3HACE1
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM.
Cell Rep 16(12):3414. doi: 10.1016/j.celrep.2016.08.072. Epub 2016 Sep 20. No abstract available. 2016
4HACE1, STX5, VCPIP1
Monoubiquitination of Syntaxin 5 Regulates Golgi Membrane Dynamics during the Cell Cycle.
Huang S, Tang D, Wang Y.
Dev Cell 38(1):73-85. doi: 10.1016/j.devcel.2016.06.001. 2016
5HACE1
HACE1 is a putative tumor suppressor gene in B-cell lymphomagenesis and is down-regulated by both deletion and epigenetic alterations.
Bouzelfen A, Alcantara M, Kora H, Picquenot JM, Bertrand P, Cornic M, Mareschal S, Bohers E, Maingonnat C, Ruminy P, Adriouch S, Boyer O, Dubois S, Bastard C, Tilly H, Latouche JB, Jardin F.
Leuk Res 45:90-100. doi: 10.1016/j.leukres.2016.04.007. Epub 2016 Apr 11. 2016
6HACE1, SPPRS
HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome.
Hollstein R, Parry DA, Nalbach L, Logan CV, Strom TM, Hartill VL, Carr IM, Korenke GC, Uppal S, Ahmed M, Wieland T, Markham AF, Bennett CP, Gillessen-Kaesbach G, Sheridan EG, Kaiser FJ, Bonthron DT.
J Med Genet 52(12):797-803. doi: 10.1136/jmedgenet-2015-103344. Epub 2015 Sep 30. 2015
7HACE1, YBX1
HACE1 mediated K27 ubiquitin linkage leads to YB-1 protein secretion.
Palicharla VR, Maddika S.
Cell Signal 27(12):2355-62. doi: 10.1016/j.cellsig.2015.09.001. Epub 2015 Sep 3. 2015
8HACE1
Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression.
Goka ET, Lippman ME.
Oncogene 34(42):5395-405. doi: 10.1038/onc.2014.468. Epub 2015 Feb 9. 2015
9HACE1, OPTN, SQSTM1
Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppression.
Liu Z, Chen P, Gao H, Gu Y, Yang J, Peng H, Xu X, Wang H, Yang M, Liu X, Fan L, Chen S, Zhou J, Sun Y, Ruan K, Cheng S, Komatsu M, White E, Li L, Ji H, Finley D, Hu R.
Cancer Cell 26(1):106-20. doi: 10.1016/j.ccr.2014.05.015. 2014
10HACE1
HACE1-dependent protein degradation provides cardiac protection in response to haemodynamic stress.
Zhang L, Chen X, Sharma P, Moon M, Sheftel AD, Dawood F, Nghiem MP, Wu J, Li RK, Gramolini AO, Sorensen PH, Penninger JM, Brumell JH, Liu PP.
Nat Commun 5:3430. doi: 10.1038/ncomms4430. 2014
11HACE1, NFE2L2
HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH.
Proc Natl Acad Sci U S A 111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. 2014
12HACE1
Methylation of the HACE1 gene is frequently detected in hepatocellular carcinoma.
Sakata M, Yokomizo K, Kitamura Y, Sakuraba K, Shirahata A, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Hibi K.
Hepatogastroenterology 60(124):781-3. doi: 10.5754/hge10439. 2013
13HACE1
HACE1 is a tumor suppressor gene candidate in natural killer cell neoplasms.
Küçük C, Hu X, Iqbal J, Gaulard P, Klinkebiel D, Cornish A, Dave BJ, Chan WC.
Am J Pathol 182(1):49-55. doi: 10.1016/j.ajpath.2012.09.012. Epub 2012 Nov 9. 2013
14HACE1
The tumour suppressor HACE1 controls cell migration by regulating Rac1 degradation.
Castillo-Lluva S, Tan CT, Daugaard M, Sorensen PH, Malliri A.
Oncogene 32(13):1735-42. doi: 10.1038/onc.2012.189. Epub 2012 May 21. 2013
15HACE1, LIN28B
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
Diskin SJ, Capasso M, Schnepp RW, Cole KA, Attiyeh EF, Hou C, Diamond M, Carpenter EL, Winter C, Lee H, Jagannathan J, Latorre V, Iolascon A, Hakonarson H, Devoto M, Maris JM.
Nat Genet 44(10):1126-30. doi: 10.1038/ng.2387. Epub 2012 Sep 2. 2012
16HACE1, RAC1
The E3 ubiquitin-ligase HACE1 catalyzes the ubiquitylation of active Rac1.
Torrino S, Visvikis O, Doye A, Boyer L, Stefani C, Munro P, Bertoglio J, Gacon G, Mettouchi A, Lemichez E.
Dev Cell 21(5):959-65. doi: 10.1016/j.devcel.2011.08.015. Epub 2011 Oct 27. 2011
17HACE1
Constitutional translocation breakpoint mapping by genome-wide paired-end sequencing identifies HACE1 as a putative Wilms tumour susceptibility gene.
Slade I, Stephens P, Douglas J, Barker K, Stebbings L, Abbaszadeh F, Pritchard-Jones K; FACT collaboration, Cole R, Pizer B, Stiller C, Vujanic G, Scott RH, Stratton MR, Rahman N.
J Med Genet 47(5):342-7. Epub 2009 Nov 30.PMID: 19948536 2010
18HACE1
Methylation of HACE1 in gastric carcinoma.
Sakata M, Kitamura YH, Sakuraba K, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y, Hibi K.
Anticancer Res 29(6):2231-3.PMID: 19528486 2009
19HACE1
HACE1: A novel repressor of RAR transcriptional activity.
Zhao J, Zhang Z, Vucetic Z, Soprano KJ, Soprano DR.
J Cell Biochem 107(3):482-93.PMID: 19350571 2009
20HACE1
Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer.
Hibi K, Sakata M, Sakuraba K, Shirahata A, Goto T, Mizukami H, Saito M, Ishibashi K, Kigawa G, Nemoto H, Sanada Y.
Anticancer Res 28(3A):1581-4.PMID: 18630515 2008
21HACE1
The E3 ligase HACE1 is a critical chromosome 6q21 tumor suppressor involved in multiple cancers.
Zhang L, Anglesio MS, O'sullivan M, Zhang F, Yang G, Sarao R, Nghiem MP, Cronin S, Hara H, Melnyk N, Li L, Wada T, Liu PP, Farrar J, Arceci RJ, Sorensen PH, Penninger JM.
Nat Med 13(9):1060-1069. Epub 2007 Aug 12. 2007
22HACE1
Differential expression of a novel ankyrin containing E3 ubiquitin-protein ligase, Hace1, in sporadic Wilms' tumor versus normal kidney.
Anglesio MS, Evdokimova V, Melnyk N, Zhang L, Fernandez CV, Grundy PE, Leach S, Marra MA, Brooks-Wilson AR, Penninger J, Sorensen PH.
Hum Mol Genet 13(18):2061-74. Epub 2004 Jul 14. 2004
23AREL1, C12orf51, HACE1, HECTD1, HECW2, HERC4, RAD23B, RAD23BL, UBE3B, UBE3C, UBR5
Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing.
Gong TW, Huang L, Warner SJ, Lomax MI.
Genomics 82(2):143-52. 2003
24ALPK3, ARHGAP21, ARHGAP28, ASH1L, BOD1L, CASKIN1, CDH6, CGN, CHD7, COG1, CPSF2, CRAMP1L, DNAH1, EBF4, EIF2AK1, EIF2AK4, FAM135A, FAM63A, FBXO41, FBXO42, FGD6, FRMD4A, G2E3, HACE1, HEATR5B, HOMEZ, IBTK, IFT80, IGSF9, JMJD1C, KCNT1, KIAA1109, KIAA1328, KIAA1377, KIAA1383, KIAA1407, KIAA1430, KIAA1432, KIF17, KLF17, KLHDC5, KLHL11, KLHL12, KLHL13, KLHL14, KLHL15, KLHL8, KLHL9, LRP2BP, LRRC7, MARCH4, MIB1, MRTFA, N4BP2, NFIA, NUFIP2, PCDH10, PDCD6IP, PDP2, PTCHD2, RBM27, RCOR3, RGAG1, ROBO2, RPAP1, SEMA6A, SH3PXD2B, SIPA1L2, STAMBPL1, STARD9, TSR1, TULP4, TXNDC16, UPF2, WDFY1, WDR11, WDR35, ZMYM6, ZNF391, ZNF395, ZNF398, ZNF471, ZNF687, ZNFX1
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O.
DNA Res 7(1):65-73. 2000