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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

ADGRG6

contributors: mct/npt/pgu - updated : 14-11-2023

HGNC name	adhesion G protein-coupled receptor G6
HGNC id	13841

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

AMCN4

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in type 2 alveolar epithelial cells is decreased in chronic obstructive pulmonary disease (COPD)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed respiratory lung chr.Bronchopathy obstructive as likely a novel therapeutic target for COPD neurology acquired   represents an attractive potential target to stimulate repair in myelin disease or following nerve injury

ANIMAL & CELL MODELS

	Gpr126 deletion causes heart phenotypes in mice causing embryonic lethality
	a mutation in Gpr126 causes a severe congenital hypomyelinating peripheral neuropathy in mice
	Gpr126-/- mice have a lethal arthrogryposis phenotype
	Gpr126-null mice with a heterozygous placenta survive but exhibit GPR126-defective peripheral nervous system (PNS) phenotype