basic FUNCTION
| may be involved in neuropeptide signaling pathway |
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playing an important role in cell-adhesion and potentially in inflammation and coagulation |
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regulates the proliferation of pulmonary arterial smooth muscle cells and airway smooth muscle cells |
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required autonomously in Schwann cells for myelination  |
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drives the differentiation of promyelinating Schwann cells by elevating cAMP levels, thereby triggering SLC22a16 expression and myelination  |
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potentially equired for embryonic viability and cardiovascular development  |
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essential for myelination and other aspects of peripheral nerve development in mammals  |
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new roles in axonal sorting, formation of mature non-myelinating Schwann cells and organization of the perineurium  |
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is required for proper trabeculation, contraction, and energy metabolism of the heart  |
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acts as a receptor to drive myelin gene expression in PNS Schwann cells, whereas in the heart, the N-terminus of GPR126 acts as a ligand or coreceptor activating an unknown receptor  |
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directly increases cAMP by coupling to heterotrimeric G-proteins  |
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functions potentially in Schwann cells for proper development and myelination and these functions are mediated via G-protein-signaling pathways  |
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modulates both physiological and pathological angiogenesis through VEGFA signaling, providing a potential target for the treatment of angiogenesis-related diseases  |
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is critical for myelination of peripheral nerves  |
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has also been implicated in bone mineralization  |
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ADGRG6 is essential for Schwann cells (SCs) development and myelination  |
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adhesion G protein-coupled receptor essential for Schwann cell (SC) myelination with important contributions to repair after nerve crush injury  |
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ADGRG6 contributes to the terminal Schwann cell response at the neuromuscular junction following peripheral nerve injury  |
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ADGRG6 extracellular regions (ECRs) utilizes a multi-faceted dynamic approach to regulate receptor function and provide relevant insights for ECR-targeted drug design  |
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ADGRG6 is essential for placental development |
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possible role of ADGRG6 in kidney physiology  |
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critical developmental roles in Schwann cell maturation and its mediated myelination in the peripheral nervous system  |
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is likely involved in mounting an epithelial inflammatory response to smoke exposure  |