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FLASH GENE

Symbol

AIFM2

contributors: - updated : 23-05-2007

HGNC name	apoptosis-inducing factor, mitochondrion-associated, 2
HGNC id	21411

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

FAD-dependent oxidoreductase family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in nitric oxide detoxification and in electron
	transport
	mitochondria-associated protein implicated in caspase-independent apoptosis
	oxidoreductase with a modified flavin cofactor and DNA binding activity

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	FAD

protein

cell & other

REGULATION

induced by

tumor suppressor protein p53 in colon cancer cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS