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FLASH GENE

Symbol

AIFM2

contributors: - updated : 23-05-2007

HGNC name	apoptosis-inducing factor, mitochondrion-associated, 2
HGNC id	21411

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary     highly Lymphoid/Immune spleen         Nervous nerve cranial nerve     highly   plexus choroid       highly Reproductive female system uterus cervix   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     highly respiratory lung alveolar epithelium macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

FAD-dependent oxidoreductase family

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,outer
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic

basic FUNCTION	involved in nitric oxide detoxification and in electron
	transport
	mitochondria-associated protein implicated in caspase-independent apoptosis
	oxidoreductase with a modified flavin cofactor and DNA binding activity

CELLULAR PROCESS	cell life, cell death/apoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	cofactor,
	FAD

protein

cell & other

REGULATION

induced by

tumor suppressor protein p53 in colon cancer cells

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS