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FLASH GENE
Symbol AIFM2 contributors: - updated : 23-05-2007
HGNC name apoptosis-inducing factor, mitochondrion-associated, 2
HGNC id 21411
DNA
TYPE functioning gene
STRUCTURE 20.00 kb     9 Exon(s)
regulatory sequence Promoter
text structure promoter containing two TP53-responsive elements
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunespleen    
Nervousnervecranial nerve  highly
 plexus choroid   highly
Reproductivefemale systemuteruscervix highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
respiratorylungalveolar epitheliummacrophage 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY FAD-dependent oxidoreductase family
CATEGORY transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria,outer
intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • involved in nitric oxide detoxification and in electron
    • transport
  • mitochondria-associated protein implicated in caspase-independent apoptosis
  • oxidoreductase with a modified flavin cofactor and DNA binding activity
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    FAD
    protein
    cell & other
    REGULATION
    induced by tumor suppressor protein p53 in colon cancer cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS