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FLASH GENE

Symbol

FOXA1

contributors: mct - updated : 25-03-2017

HGNC name	forkhead box A1
HGNC id	5021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in esophageal squamous cell carcinoma and in breast cancer tumoral     --low   is associated with better survival in the breast cancer constitutional       gain of function in both replicative and oncogene-induced senescence, and in turn activates transcription of CDKN2A through multiple mechanisms ( tumoral somatic mutation       in prostate cancer

Susceptibility

to breast cancer

Variant & Polymorphism SNP	many of the SNPs associated with breast cancer risk may be modulating the same biological process, namely, DNA affinity for FOXA1, a key regulator of ER activity

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer reproductive breast target fo breast cancer diabete     could be a novel therapeutic target for insulin resistance digestive liver   could be a novel therapeutic target for nonalcoholic fatty liver disease

ANIMAL & CELL MODELS