| basic FUNCTION
| activator of gene expression in hepatocytes, respiratory and intestinal epithelia |
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cooperating with GRL to activate genes that code for proteins involved in glucose homeostasis, namely PEPCK (PCK1, PCK2), TAT, IGFBP1, unlikely to be a common cause of NIDDM |
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involved in mediating an estrogen response via ESR1 |
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important regulator of MUC2 expression in the intestine |
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playing an important role in MUC2 mucin expression in the intestine during goblet cell differentiation |
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controls downstream transcription of oestrogen receptor (ER)-regulated genes  |
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independent prognostic significance in breast cancer |
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cooperate with FOXA2 during liver and lung morphogenesis |
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up-regulating HSPA1A in MCF7 breast cancer cell line |
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regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner |
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role for HDAC7 and FOXA1 in estrogen repression of RPRM, a mechanism which could potentially be generalized to many more estrogen-repressed genes and hence be important in both normal physiology and pathological processes |
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critical for the androgenic regulation of prostate-specific promoters |
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directly regulates HOXB13 in human prostate epithelial cells |
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contributes to gene regulation by its ability to act as a pioneer factor that binds to nucleosomal DNA |
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critical for the androgenic regulation of prostate-specific promoters |
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major determinant of estrogen-ESR1 activity and endocrine response in breast cancer cells |
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sufficient to permit ESR1-chromatin interactions and transcriptional activity in diverse target tissues |
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plays a suppressive role in the early phase of adipogenesis, acting under the control of CEBPB, and might be involved in the regulation of the rate of progression of the early phase of adipogenesis |
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critical mediator of nuclear steroid receptor signalling, manifest at least in part through regulation of androgen receptor and oestrogen receptor activity |
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major role for FOXA1 in modulating nuclear steroid receptor activity in breast and prostate cancer, and FOXA1 may significantly contribute to pro-tumourigenic phenotypes |
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the role of FOXA1 in androgen signalling and prostate cancer is distinctly different from that in oestrogen signalling and breast cancer |
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required for postnatal survival due to its essential role in controlling pancreatic and renal function |
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play important roles in controlling both metabolism and homeostasis through the regulation of multiple target genes in the liver, pancreas and adipose tissue |
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potent inhibitor of hepatic triglyceride synthesis, accumulation and secretion by repressing the expression of multiple target genes of these pathways |
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FOXA1, FOXA2 are required for activation of SHH in the notochord |
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critical interacting partner of the nuclear hormone receptors, ESR1 and androgen receptor (AR), which are major drivers of the two most common cancers, namely breast and prostate cancer ( |
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a later role for FOXA1, FOXA2 genes in regulating the maintenance of dopaminergic phenotype in mesodiencephalic dopaminergic (mDA) neurons |
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FOXA1 and FOXA2 control glucagon biosynthesis and secretion as well as alpha-cell differentiation with both common and unique target genes |
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FOXA1 recruits likely the chromatin modifier KMT2C to facilitate the deposition of H3K4me1 histone marks, subsequently demarcating active enhancer elements |
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SMARCD3 acts with FOXA1 to control lipid and fatty acid metabolism, programs associated with therapy resistance and poor prognosis in cancer |
