Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol PLEKHG5 contributors: mct - updated : 04-06-2016
HGNC name pleckstrin homology domain containing, family G (with RhoGef domain) member 5
HGNC id 29105
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
intracellular,nuclear envelope
basic FUNCTION
  • may play a role in regulating lymphocyte homeostasis
  • activating RhoA and involved in the control of neuronal cell differentiation
  • regulates RhoA signaling pathways in developing and mature forebrain neurons
  • recruited to junctions by members of the Crumbs polarity complex and promoted junction integrity by activating Diaphanous
  • importance of PLEKHG5 function in maintaining stable cell-cell contacts
  • RHOA-specific guanine nucleotide exchange factor PLEKHG5 is required for the polarity of actively migrating brain and breast tumor cells (PMID
  • recruitment of PLEKHG5 to the cell membrane and the subsequent selective activation of DIAPH1 signaling, coupled with the suppression of ROCK1 and activation of cofilin-mediated actin reorganization, plays a key role in establishing cell polarity during directed cell migration (PMID
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component AMOT forms a ternary complex together with INADL (or its paralogue MPDZ) and PLEKHG5
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with the adapter TRADD
  • RND3 effector that interacts with RNDs via a RAF1-like Ras-binding domain
  • RND1, RND2, and RND3 stability is acutely dependent on interaction with their effectors such as PLEKHG5 or ARHGAP35
  • VEGFA caused translocation of PLEKHG5 from cell junctions, promoting junction disassembly, whereas ANGPT1 maintained PLEKHG5 at the junctions, inducing junction stabilization
  • binding of 14-3-3 proteins inhibits the GEF activity of PLEKHG5
  • may interact with a variety of partners including multiple PDZ domain protein 1 [MUPP1 or MPDZ)
  • function of PLEKHG5 is mediated by the selective activation of the RHOA downstream effector DIAPH1 (PMID
  • VEGFA induced interactions between NRP1 and GIPC1, a scaffold protein, and complex formation between GIPC1 and PLEKHG5, a RhoGEF
    • cell & other
    REGULATION
    repressed by RND3 (negatively regulates PLEKHG5, and that as a RhoA-GEF it plays a key role in early embryonic cell shape changes)
    ASSOCIATED DISORDERS
    corresponding disease(s) LMND2 , RICMTC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • syx(-/-) mice had defective junctions, resulting in vascular leakiness, edema, and impaired heart function