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FLASH GENE

Symbol

KLK3

contributors: mct - updated : 16-04-2020

HGNC name	kallikrein-related peptidase 3
HGNC id	6364

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   lower in malignant than in normal prostatic epithelium and it is further reduced in poorly differentiated tumors constitutional germinal mutation     loss of function could lead to false-negative KLK3 findings used for screening, diagnosis, or monitoring of Prostate carcinoma

Susceptibility

to prostate cancer (minor role) (PCa) to infertility

Variant & Polymorphism SNP , other	two A-alleles have increased risk for prostate cancer onset under the age of 67
	SNP increasing the risk of prostate cancer
	rs17632542, introduces a non-synonymous amino acid change in the KLK3 protein with a predicted benign or neutral functional impact, and could influence the diagnosis of nonaggressive prostate cancer
	five SNPs, rs266881, rs174776, rs266875, rs35192866 and rs1810020 correlated with an increased risk of infertility

Candidate gene	early marker for the presence of prostate cancer, prostate-specific antigen, being the current serum biomarker for prostate cancer
	biomarker potential for chromophobe renal cell carcinoma
	polymorphism T>C of rs1058205 was associated with decreased risk of PCa
Marker	only independent predictor of extensive lymph node invasion (LNI) in prostate cancer and could be an important preoperative factor for stratifying high-risk patients
	OPSAD (the ratio of KLK3 to the outer gland volume of prostate) may be used as a new indicator for the diagnosis and prognosis of prostate cancer, and it can reduce the use of unnecessary puncture biopsy of the prostate
	KLK3 is a marker of Testosterone concentrations and it may represent a new tool in confirming hypogonadism
Therapy target
	System Type Disorder Pubmed cancer reproductive prostate potential target for tumor imaging and treatment in prostate cancer cells

ANIMAL & CELL MODELS