| 1 | KLK3
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| Prostatic-specific antigen (PSA) levels in patients with polycystic ovary syndrome (PCOS): a meta-analysis.
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| Wu ZH, Tang Y, Niu X, Pu FF, Xiao XY, Kong W.
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| J Ovarian Res 12(1):94. doi: 10.1186/s13048-019-0569-2. Review.
2019
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| 2 | CTSD, FIGF, KLK3, VEGFC
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| KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D.
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| Jha SK, Rauniyar K, Chronowska E, Mattonet K, Maina EW, Koistinen H, Stenman UH, Alitalo K, Jeltsch M.
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| Elife 8. pii: e44478. doi: 10.7554/eLife.44478.
2019
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| 3 | KLK10, KLK15, KLK2, KLK3, KLK6, KLK7, KLK8
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| Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types.
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| Tailor PD, Kodeboyina SK, Bai S, Patel N, Sharma S, Ratnani A, Copland JA, She JX, Sharma A.
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| Oncotarget 9(25):17876-17888. doi: 10.18632/oncotarget.24947. eCollection 2018 Apr 3.
2018
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| 4 | KLK2, KLK3, KLK4, kLK11
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| Activation and activity of glycosylated KLKs 3, 4 and 11.
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| Guo S, Briza P, Magdolen V, Brandstetter H, Goettig P.
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| Biol Chem 399(9):1009-1022. doi: 10.1515/hsz-2018-0148.
2018
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| 5 | KLK3
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| Association between three genetic variants in kallikrein 3 and prostate cancer risk.
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| Ding WH, Ren KW, Yue C, Zou JG, Zuo L, Zhang LF, Bai Y, Okada A, Yasui T, Mi YY.
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| Biosci Rep 38(6). pii: BSR20181151. doi: 10.1042/BSR20181151. Print 2018 Dec 21.
2018
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| 6 | KLK3
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| Prostate-specific antigen associates with extensive lymph node invasion in high-risk prostate cancer.
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| Porcaro AB, Corsi P, Inverardi D, Sebben M, Tafuri A, Processali T, Mattevi D, De Marchi D, Pirozzi M, Cerruto MA, Amigoni N, Rizzetto R, Brunelli M, Siracusano S, Artibani W.
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| Tumori 104(4):307-311. doi: 10.1177/0300891618765567. Epub 2018 Apr 6.
2018
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| 7 | KLK3
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| Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility.
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| Gupta N, Sudhakar DVS, Gangwar PK, Sankhwar SN, Gupta NJ, Chakraborty B, Thangaraj K, Gupta G, Rajender S.
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| Sci Rep 7(1):11225. doi: 10.1038/s41598-017-10866-1.
2017
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| 8 | ESR1, KLK3
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| Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo.
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| Li S, Garcia M, Gewiss RL, Winuthayanon W.
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| PLoS Genet 13(4):e1006743. doi: 10.1371/journal.pgen.1006743. eCollection 2017 Apr.
2017
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| 9 | ANXA1, CRISP3, KLK3
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| Cysteine-rich secretory protein 3 plays a role in prostate cancer cell invasion and affects expression of PSA and ANXA1.
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| Pathak BR, Breed AA, Apte S, Acharya K, Mahale SD.
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| Mol Cell Biochem 411(1-2):11-21. doi: 10.1007/s11010-015-2564-2. Epub 2015 Sep 14. 2016
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| 10 | KLK2, KLK3
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| A Single Glycan at the 99-Loop of Human Kallikrein-related Peptidase 2 Regulates Activation and Enzymatic Activity.
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| Guo S, Skala W, Magdolen V, Briza P, Biniossek ML, Schilling O, Kellermann J, Brandstetter H, Goettig P.
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| J Biol Chem 291(2):593-604. doi: 10.1074/jbc.M115.691097. Epub 2015 Nov 18.
2016
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| 11 | KLK3
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| PCA3 and PSA gene activity correlates with the true tumor cell burden in prostate cancer lymph node metastases.
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| Tsaur I, Hennenlotter J, Oppermann E, Munz M, Kuehs U, Stenzl A, Schilling D.
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| Cancer Biomark 15(3):311-6. doi: 10.3233/CBM-150461.
2015
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| 12 | KLK3
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| Ratio of prostate specific antigen to the outer gland volume of prostrate as a predictor for prostate cancer.
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| Zhang HM, Yan Y, Wang F, Gu WY, Hu GH, Zheng JH.
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| Int J Clin Exp Pathol 7(9):6079-84. eCollection 2014.
2014
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| 13 | KLK3
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| Proteolytic activity of prostate-specific antigen (PSA) towards protein substrates and effect of peptides stimulating PSA activity.
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| Mattsson JM, Ravela S, Hekim C, Jonsson M, Malm J, Närvänen A, Stenman UH, Koistinen H.
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| PLoS One 9(9):e107819. doi: 10.1371/journal.pone.0107819. eCollection 2014.
2014
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| 14 | KLK2, KLK3
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| Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.
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| Skala W, Utzschneider DT, Magdolen V, Debela M, Guo S, Craik CS, Brandstetter H, Goettig P.
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| J Biol Chem 289(49):34267-83. doi: 10.1074/jbc.M114.598201. Epub 2014 Oct 16.
2014
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| 15 | KLK3
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| Serum PSA as a predictor of testosterone deficiency.
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| Rastrelli G, Corona G, Vignozzi L, Maseroli E, Silverii A, Monami M, Mannucci E, Forti G, Maggi M.
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| J Sex Med 10(10):2518-28. doi: 10.1111/jsm.12266. Epub 2013 Jul 16.
2013
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| 16 | KLK3
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| Very low PSA concentrations and deletions of the KLK3 gene.
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| Rodriguez S, Al-Ghamdi OA, Burrows K, Guthrie PA, Lane JA, Davis M, Marsden G, Alharbi KK, Cox A, Hamdy FC, Neal DE, Donovan JL, Day IN.
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| Clin Chem 59(1):234-44. doi: 10.1373/clinchem.2012.192815. Epub 2012 Nov 20.
2013
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| 17 | KLK3
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| Long terminal repeats act as androgen-responsive enhancers for the PSA-kallikrein locus.
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| Lawrence MG, Stephens CR, Need EF, Lai J, Buchanan G, Clements JA.
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| Endocrinology 153(7):3199-210. doi: 10.1210/en.2012-1267. Epub 2012 May 17.
2012
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| 18 | KLK3
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| Fine mapping the KLK3 locus on chromosome 19q13.33 associated with prostate cancer susceptibility and PSA levels.
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| Parikh H, Wang Z, Pettigrew KA, Jia J, Daugherty S, Yeager M, Jacobs KB, Hutchinson A, Burdett L, Cullen M, Qi L, Boland J, Collins I, Albert TJ, Vatten LJ, Hveem K, Njølstad I, Cancel-Tassin G, Cussenot O, Valeri A, Virtamo J, Thun MJ, Feigelson HS, Diver WR, Chatterjee N, Thomas G, Albanes D, Chanock SJ, Hunter DJ, Hoover R, Hayes RB, Berndt SI, Sampson J, Amundadottir L.
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| Hum Genet 129(6):675-85. Epub 2011 Feb 15.
2011
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| 19 | KLK3
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| Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript.
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| Kote-Jarai Z, Amin Al Olama A, Leongamornlert D, Tymrakiewicz M, Saunders E, Guy M, Giles GG, Severi G, Southey M, Hopper JL, Sit KC, Harris JM, Batra J, Spurdle AB, Clements JA, Hamdy F, Neal D, Donovan J, Muir K, Pharoah PD, Chanock SJ, Brown N, Benlloch S, Castro E, Mahmud N, O'Brien L, Hall A, Sawyer E, Wilkinson R, Easton DF, Eeles RA.
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| Hum Genet 129(6):687-94. Epub 2011 Apr 5.
2011
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| 20 | KLK2, KLK3
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| Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen and the Extended Kallikrein Locus.
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| Lawrence MG, Lai J, Clements JA.
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| Endocr Rev ndocr Rev. 2010 Jan 26. [Epub ahead of print]PMID: 20103546 2010
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| 21 | KLK15, KLK2, KLK3
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| A comprehensive resequence analysis of the KLK15-KLK3-KLK2 locus on chromosome 19q13.33.
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| Parikh H, Deng Z, Yeager M, Boland J, Matthews C, Jia J, Collins I, White A, Burdett L, Hutchinson A, Qi L, Bacior JA, Lonsberry V, Rodesch MJ, Jeddeloh JA, Albert TJ, Halvensleben HA, Harkins TT, Ahn J, Berndt SI, Chatterjee N, Hoover R, Thomas G, Hunter DJ, Hayes RB, Chanock SJ, Amundadottir L.
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| Hum Genet 127(1):91-9. Epub 2009 Oct 13.PMID: 19823874 2010
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| 22 | KLK3, TRPM8
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| PSA reduces prostate cancer cell motility by stimulating TRPM8 activity and plasma membrane expression.
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| Gkika D, Flourakis M, Lemonnier L, Prevarskaya N.
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| Oncogene 29(32):4611-6. Epub 2010 Jun 7. 2010
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| 23 | KLK3
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| Variation in KLK genes, prostate-specific antigen and risk of prostate cancer.
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| Ahn J, Berndt SI, Wacholder S, Kraft P, Kibel AS, Yeager M, Albanes D, Giovannucci E, Stampfer MJ, Virtamo J, Thun MJ, Feigelson HS, Cancel-Tassin G, Cussenot O, Thomas G, Hunter DJ, Fraumeni JF Jr, Hoover RN, Chanock SJ, Hayes RB.
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| Nat Genet 40(9):1032-4. No abstract available.
2008
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| 24 | MSMB, LMTK2, KLK3
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| Multiple newly identified loci associated with prostate cancer susceptibility.
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| Eeles RA, Kote-Jarai Z, Giles GG, Olama AA, Guy M, Jugurnauth SK, Mulholland S, Leongamornlert DA, Edwards SM, Morrison J, Field HI, Southey MC, Severi G, Donovan JL, Hamdy FC, Dearnaley DP, Muir KR, Smith C, Bagnato M, Ardern-Jones AT, Hall AL, O'Brien LT, Gehr-Swain BN, Wilkinson RA, Cox A, Lewis S, Brown PM, Jhavar SG, Tymrakiewicz M, Lophatananon A, Bryant SL; UK Genetic Prostate Cancer Study Collaborators; British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators, Horwich A, Huddart RA, Khoo VS, Parker CC, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Fisher C, Jamieson C, Cooper CS, English DR, Hopper JL, Neal DE, Easton DF.
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| Nat Genet 40(3):316-21. Epub 2008 Feb 10. 2008
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| 25 | CMTM3, KLK3
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| CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells.
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| Wang Y, Li T, Qiu X, Mo X, Zhang Y, Song Q, Ma D, Han W.
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| Biochem Biophys Res Commun 371(1):54-8. Epub 2008 Apr 8. 2008
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| 26 | KLK2, KLK3
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| Development of peptides specifically modulating the activity of KLK2 and KLK3.
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| Koistinen H, Närvänen A, Pakkala M, Hekim C, Mattsson JM, Zhu L, Laakkonen P, Stenman UH.
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| Biol Chem 389(6):633-42. Review.PMID: 18627344 2008
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| 27 | KLK10, KLK11, KLK14, KLK3
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| Intracellular signaling pathways regulate hormone-dependent kallikrein gene expression.
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| Paliouras M, Diamandis EP.
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| Tumour Biol 29(2):63-75. Epub 2008 Jun 2.PMID: 18515984 2008
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| 28 | KLK1, KLK11, KLK14, KLK3
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| Human kallikrein-related peptidase 14 (KLK14) is a new activator component of the KLK proteolytic cascade. Possible function in seminal plasma and skin.
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| Emami N, Diamandis EP.
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| J Biol Chem 283(6):3031-41. Epub 2007 Dec 3.PMID: 18056261 2008
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| 29 | KLK2, KLK3
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| Activity and stability of human kallikrein-2-specific linear and cyclic peptide inhibitors.
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| Pakkala M, Hekim C, Soininen P, Leinonen J, Koistinen H, Weisell J, Stenman UH, Vepsäläinen J, Närvänen A.
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| J Pept Sci 13(5):348-53.PMID: 17436344 2007
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| 30 | KLK13, KLK2, KLK3, KLK5, KLK6, KLK7, KLK8
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| Distribution of 15 human kallikreins in tissues and biological fluids.
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| Shaw JL, Diamandis EP.
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| Clin Chem 53(8):1423-32. Epub 2007 Jun 15.PMID: 17573418 2007
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| 31 | VDR, KLK3
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| Association of vitamin D receptor FokI polymorphism with prostate cancer risk, clinicopathological features and recurrence of prostate specific antigen after radical prostatectomy.
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| Huang SP, Huang CY, Wu WJ, Pu YS, Chen J, Chen YY, Yu CC, Wu TT, Wang JS, Lee YH, Huang JK, Huang CH, Wu MT.
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| Int J Cancer 119(8):1902-7. 2006
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| 32 | SEMG1, SEMG2, KLK3
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| Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen.
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| Jonsson M, Linse S, Frohm B, Lundwall A, Malm J.
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| Biochem J 387(Pt 2):447-53. 2005
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| 33 | KLK3
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| Expression of prostate specific membrane antigen in androgen-independent prostate cancer cell line PC-3.
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| Laidler P, Dulinska J, Lekka M, Lekki J.
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| Arch Biochem Biophys 435(1):1-14. 2005
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| 34 | KLK3
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| Identification of a novel transcription factor, GAGATA-binding protein, involved in androgen-mediated expression of prostate-specific antigen.
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| Wang C, Yeung F, Liu PC, Attar RM, Geng J, Chung LW, Gottardis M, Kao C.
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| J Biol Chem 278(34):32423-30. Epub 2003 Jun 2. 2003
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| 35 | KLK3, NKX3-1, SPDEF
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| NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter.
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| Chen H, Nandi AK, Li X, Bieberich CJ.
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| Cancer Res 62(2):338-40. 2002
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| 36 | KLK3
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| Linkage between polymorphisms in the prostate specific antigen ARE1 gene region, prostate cancer risk, and circulating tumor cells.
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| Medeiros R, Morais A, Vasconcelos A, Costa S, Pinto D, Oliveira J, Carvalho R, Lopes C.
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| Prostate 53(1):88-94. 2002
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| 37 | KLK2, KLK3
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| Unusual alternative splicing within the human kallikrein genes KLK2 and KLK3 gives rise to novel prostate-specific proteins.
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| David A, Mabjeesh N, Azar I, Biton S, Engel S, Bernstein J, Romano J, Avidor Y, Waks T, Eshhar Z, Langer SZ, Lifschitz-Mercer B, Matzkin H, Rotman G, Toporik A, Savitsky K, Mintz L.
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| J Biol Chem 277(20):18084-90. Epub 2002 Feb 7.
2002
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| 38 | KLK3
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| Characterization of PSA-RP2, a protein related to prostate-specific antigen and encoded by alternative hKLK3 transcripts.
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| Heuze-Vourc'h N, Leblond V, Olayat S, Gauthier F, Courty Y.
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| Eur J Biochem 268(16):4408-13. 2001
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| 39 | KLK1, KLK10, KLK11, KLK12, KLK13, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9
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| Tissue-specific expression patterns and fine mapping of the human kallikrein (KLK) locus on proximal 19q13.4.
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| Harvey TJ, Hooper JD, Myers SA, Stephenson SA, Ashworth LK, Clements JA.
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| J Biol Chem 275(48):37397-406.
2000
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| 40 | KLK3
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| The promoter and the enhancer region of the KLK 3 (prostate specific antigen) gene is frequently mutated in breast tumours and in breast carcinoma cell lines.
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| Majumdar S, et al.
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| Br J Cancer 79(9-10):1594-602. 1999
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| 41 | KLK3
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| Molecular cloning and expression of an alternative hKLK3 transcript coding for a variant protein of prostate-specific antigen.
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| Heuze N, et al.
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| Cancer Res 59(12):2820-4. 1999
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| 42 | KLK1, KLK2, KLK3, KLKB1
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| Refined mapping and colocalization of the human genes for prostate-specific antigen and pancreatic kallikrein to 19q13.3.
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| Winqvist R, et al.
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| (HGM11) Cytogenet Cell Genet 58 : 2026. 1991
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| 43 | KLK1, KLK2, KLK3, KLKB1
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| Refined mapping and colocalization of the human prostate-specific antigen and pancreatic kallikrein genes to 19q13.3.
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| Winqvist R, et al.
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| Am J Hum Genet 47 : A265. 1990
|