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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

NELL1

contributors: mct/npt/pgu - updated : 04-03-2014

HGNC name	NEL-like 1 (chicken)
HGNC id	7750

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --over   in craniofacial anomalies, premature suture closure tumoral     --low   by promoter hypermethylation in early-stage esophageal adenocarcinoma, occuring early during Barrett's-associated esophageal neoplastic progression, and is a potential biomarker of poor prognosis in early-stage EAC tumoral     --other   expressed mainly in tumors in the neuronal cell lineage

Susceptibility

Variant & Polymorphism

Candidate gene	candidate growth factor able to induce human perivascular stem cells osteogenesis
Marker
Therapy target
	System Type Disorder Pubmed osteoarticular bone   future therapeutic utility of NELL1 for either skeletal or soft-tissue regenerative medicine

ANIMAL & CELL MODELS

Nell-1 overexpressing mice demonstrate calvarial bone overgrowth and inappropriate cranial suture fusion