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FLASH GENE
Symbol ABI2 contributors: KTN/npt - updated : 04-02-2009
HGNC name abl interactor 2
HGNC id 24011
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a t-SNARE coiled-coil homology domain
  • an SH3 domain
  • several polyproline stretches, proline-rich sequences critical for binding to c-Abl
    • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to rattus Abi2 (98.9 pc)
    homolog to murine Abi2 (99.3 pc)
    Homologene
    FAMILY
  • ABI family
    • CATEGORY adaptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    text localized in lamellipodia and filopodia (Stradal 2001)
    basic FUNCTION
  • may be functioning as a tumor suppressor (Dai 1995)
  • may act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2 (Dai 1995)
  • may be involved in cytoskeletal reorganization (Stradal 2001)
  • involved in actin polymerization or depolymerization
  • regulating ABL1/c-Abl-mediated phosphorylation of EGFR (Hirao 2006)
  • being a SH3/SH2 adaptor
    • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ABL1 and ABL2 (Dai 1995)
  • binding to TRIM32 (Kano 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS