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	HGNC	UniGene	Nucleotide	OMIM	UCSC

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FLASH GENE

Symbol

EGFL7

contributors: mct/pgu - updated : 09-11-2013

HGNC name	EGF-like-domain, multiple 7
HGNC id	20594

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly upregulated in human epithelial tumor tissues tumoral     --over   expression is significantly higher in invasive ductal than in invasive lobular breast carcinoma constitutional     --low   with ACVRL1 showed lower expression in early-onset pre-eclampsia versus late-onset pre-eclampsia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	potential biomarker for human epithelial tumors, especially hepatocellular carcinoma and breast cancer
Therapy target
	System Type Disorder Pubmed cancer     anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy

ANIMAL & CELL MODELS