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FLASH GENE
Symbol EGFL7 contributors: mct/pgu - updated : 09-11-2013
HGNC name EGF-like-domain, multiple 7
HGNC id 20594
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
significantly upregulated in human epithelial tumor tissues
tumoral     --over  
expression is significantly higher in invasive ductal than in invasive lobular breast carcinoma
constitutional     --low  
with ACVRL1 showed lower expression in early-onset pre-eclampsia versus late-onset pre-eclampsia
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • potential biomarker for human epithelial tumors, especially hepatocellular carcinoma and breast cancer
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy
    ANIMAL & CELL MODELS